Multicomponent peptide assemblies

• Published in: Chemical Society reviews 2018-05, Vol.47 (1), p.3659-372
• Main Authors: Raymond, Danielle M, Nilsson, Bradley L
• Format: Article
• Language: English
• Subjects: Assemblies; Biomimetics; Formulations; Low molecular weights; Molecular chains; Molecular Weight; Nanomaterials; Nanostructures - chemistry; Peptides; Peptides - chemical synthesis; Peptides - chemistry; Properties (attributes); Protein Conformation; Self-assembly
• ISSN: 0306-0012; 1460-4744; 1460-4744
• DOI: 10.1039/c8cs00115d

Self-assembled peptide nanostructures have been increasingly exploited as functional materials for applications in biomedicine and energy. The emergent properties of these nanomaterials determine the applications for which they can be exploited. It has recently been appreciated that nanomaterials composed of multicomponent coassembled peptides often display unique emergent properties that have the potential to dramatically expand the functional utility of peptide-based materials. This review presents recent efforts in the development of multicomponent peptide assemblies. The discussion includes multicomponent assemblies derived from short low molecular weight peptides, peptide amphiphiles, coiled coil peptides, collagen, and β-sheet peptides. The design, structure, emergent properties, and applications for these multicomponent assemblies are presented in order to illustrate the potential of these formulations as sophisticated next-generation bio-inspired materials. This review presents recent efforts in the development of multicomponent supramolecular peptide assemblies with a focus on multicomponent assemblies derived from β-sheet peptides, low molecular weight peptides, peptide amphiphiles, coiled coil peptides, collagen, and related systems.