Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome

Objective: To measure the expression of proinflammatory, anti-inflammatory cytokines, and receptor activator NK-κB ligand (RANKL)/osteoprotegerin (OPG) in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, and to assess the relationship between those factors and disease activi...

Full description

Saved in:
Bibliographic Details
Published in:Modern rheumatology 2019-05, Vol.29 (3), p.523-530
Main Authors: Zhang, Shuo, Li, Chen, Zhang, Siya, Li, Li, Zhang, Weihong, Dong, Zhenhua, Zhang, Wen
Format: Article
Language:English
Subjects:
Acquired Hyperostosis Syndrome - blood
Adult
Biomarkers - blood
cytokines
Cytokines - blood
Female
Humans
inflammation
Male
Middle Aged
Osteoprotegerin - blood
RANK Ligand - blood
RANKL/OPG
SAPHO syndrome
T cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To measure the expression of proinflammatory, anti-inflammatory cytokines, and receptor activator NK-κB ligand (RANKL)/osteoprotegerin (OPG) in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, and to assess the relationship between those factors and disease activity. Methods: We studied 30 cases of SAPHO syndrome and 15 healthy controls. According to the Visual Analogue Scale (VAS) pain scores and Bath Ankylosing Spondylitis Activity Index (BASDAI), patients were divided into active group and stable group. The serum levels of IFN-γ, TNF-α, TGF-β1, IL-1β, IL-4, IL-6, IL-8, IL-17A, IL-22, RANKL, and OPG were determined by ELISA. Results: The active group IL-6 (2.34 ± 1.31 pg/ml), IL-8 (36.41 ± 12.93 pg/ml), and IL-17A (29.17 ± 4.01 pg/ml) levels were significantly higher than those in the stable group (p 
ISSN:1439-7595
1439-7609
DOI:10.1080/14397595.2018.1469580