In the Absence of CD154, Administration of Interleukin-12 Restores Th1 Responses but Not Protective Immunity to Schistosoma mansoni

• Published in: Infection and Immunity 2007-07, Vol.75 (7), p.3539-3547
• Main Authors: HEWITSON, James P, HAMBLIN, Paul A, MOUNTFORD, Adrian P
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Helminth - blood; Biological and medical sciences; CD40 Ligand - deficiency; CD40 Ligand - genetics; CD40 Ligand - metabolism; Female; Fundamental and applied biological sciences. Psychology; Fungal and Parasitic Infections; Host parasite relation; pathogenicity; Interleukin-12 - administration & dosage; Interleukin-12 - immunology; Invertebrates; Lung - immunology; Lung - parasitology; Mice; Mice, Inbred C57BL; Nemathelminthia. Plathelmintha; Recombinant Proteins - administration & dosage; Recombinant Proteins - immunology; Schistosoma mansoni; Schistosoma mansoni - growth & development; Schistosoma mansoni - immunology; Schistosoma mansoni - pathogenicity; Schistosoma mansoni - radiation effects; Schistosomiasis mansoni - immunology; Schistosomiasis mansoni - parasitology; Schistosomiasis mansoni - prevention & control; Th1 Cells - immunology; Vaccination; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; Vaccines, Attenuated - radiation effects
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.00252-07

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