Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab

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Bibliographic Details
Published in:Allergology international 2018-09, Vol.67, p.S41-S44
Main Authors: Arakawa, Sayaka, Suzukawa, Maho, Ohshima, Nobuharu, Tashimo, Hiroyuki, Asari, Isao, Matsui, Hirotoshi, Kobayashi, Nobuyuki, Shoji, Shunsuke, Nagase, Takahide, Ohta, Ken
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal, Humanized - therapeutic use
Antigens, CD - blood
Antigens, CD - genetics
Antigens, CD - metabolism
Antigens, Differentiation, B-Lymphocyte - blood
Antigens, Differentiation, B-Lymphocyte - genetics
Antigens, Differentiation, B-Lymphocyte - metabolism
Asthma - diagnosis
Asthma - drug therapy
Asthma - metabolism
Biomarkers
Eosinophilia - pathology
Female
Gene Expression
Humans
Interleukin-5 - blood
Interleukin-5 - metabolism
Lectins - blood
Lectins - genetics
Lectins - metabolism
Male
Middle Aged
Respiratory Function Tests
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ISSN:1323-8930
1440-1592
DOI:10.1016/j.alit.2018.03.006