Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice

The present study was aimed to investigate the effect of Urtica dioica Linn. (UD) extract against chronic diabetes mediated anxiogenic and depressive like behavior in mice. Streptozotocin (STZ) (50 mg/kg, i.p.) for 5 consecutive days was used to induce diabetes followed by treatment with UD leaves e...

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Bibliographic Details
Published in:Metabolic brain disease 2018-08, Vol.33 (4), p.1281-1292
Main Authors: Patel, Sita Sharan, Ray, R. S., Sharma, Arun, Mehta, Vineet, Katyal, Anju, Udayabanu, Malairaman
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
Antidepressants
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Anxiety
Anxiety - drug therapy
Anxiety - metabolism
Apoptosis
Autophagy
Autophagy - drug effects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cyclin D1
Cyclin D1 - metabolism
Deoxyribonucleic acid
Depression - drug therapy
Depression - metabolism
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
DNA
DNA damage
DNA fragmentation
Down-Regulation - drug effects
Gene expression
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Leaves
Male
Metabolic Diseases
Mice
Neurology
Neurosciences
Nitric-oxide synthase
Oncology
Original Article
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Proto-Oncogene Proteins c-bcl-2 - metabolism
Rodents
Rosiglitazone
Rosiglitazone - pharmacology
Rosiglitazone - therapeutic use
Streptozocin
TrkB receptors
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
Urtica dioica
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Summary:The present study was aimed to investigate the effect of Urtica dioica Linn. (UD) extract against chronic diabetes mediated anxiogenic and depressive like behavior in mice. Streptozotocin (STZ) (50 mg/kg, i.p.) for 5 consecutive days was used to induce diabetes followed by treatment with UD leaves extract (50 mg/kg, p.o.) and rosiglitazone (ROSI) (5 mg/kg, p.o.) for 8 weeks. STZ induced chronic diabetes significantly induced anxiety and depressive like behavior in mice. Chronic diabetes significantly downregulated BDNF ( p  
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-018-0243-1