Rapid increase of ‘brain-type’ transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery

Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a dementia-inducing disorder. Primary cause of iNPH is speculated to be a reduction of cerebrospinal fluid (CSF) absorption, which secondarily induces hydrocephalus, compression of brain, and reduction of CSF production. Patients are treate...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2018-09, Vol.164 (3), p.205-213
Main Authors: Murakami, Yuta, Matsumoto, Yuka, Hoshi, Kyoka, Ito, Hiromi, Fuwa, Takashi J, Yamaguchi, Yoshiki, Nakajima, Madoka, Miyajima, Masakazu, Arai, Hajime, Nollet, Kenneth, Kato, Naho, Nishikata, Rie, Kuroda, Naohito, Honda, Takashi, Sakuma, Jun, Saito, Kiyoshi, Hashimoto, Yasuhiro
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Idiopathic normal pressure hydrocephalus (iNPH) is a dementia-inducing disorder. Primary cause of iNPH is speculated to be a reduction of cerebrospinal fluid (CSF) absorption, which secondarily induces hydrocephalus, compression of brain, and reduction of CSF production. Patients are treated by surgically inserting a shunt to deliver excess CSF to the abdominal cavity. The prognosis for cognitive improvement after shunt surgery has been difficult to predict. We therefore investigated various CSF proteins, hoping to find a biomarker predictive of cognitive performance one to two years after shunt surgery. CSF proteins of 34 iNPH and 15 non-iNPH patients were analysed by Western blotting, revealing two glycan isoforms of transferrin (Tf); ‘brain-type’ Tf with N-acetylglucosaminylated glycans and ‘serum-type’ Tf with α2, 6-sialylated glycans. Brain-type Tf levels decreased in iNPH but rapidly returned to normal levels within 1–3 months after shunt surgery. This change was positively correlated with recovery from dementia, per Mini-Mental State Examination and Frontal Assessment Battery scores at 11.8 ± 7.7 months post-operation, suggesting that brain-type Tf is a prognostic marker for recovery from dementia after shunt surgery for iNPH. Histochemical staining with anti-Tf antibody and an N-acetylglucosamine-binding lectin suggests that brain-type Tf is secreted from choroid plexus, CSF-producing tissue.
ISSN:0021-924X
1756-2651
DOI:10.1093/jb/mvy043