Cost‐effectiveness of first‐trimester screening with early preventative use of aspirin in women at high risk of early‐onset pre‐eclampsia

ABSTRACT Objective Pre‐eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first‐trimester screening algorithm predicting the risk of early‐onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11–13 weeks in women ident...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2019-02, Vol.53 (2), p.239-244
Main Authors: Ortved, D., Hawkins, T. L.‐A., Johnson, J.‐A., Hyett, J., Metcalfe, A.
Format: Article
Language:English
Subjects:
Algorithms
Aspirin
Computer simulation
Cost analysis
Cost engineering
cost‐effectiveness
Decision analysis
Decision theory
early‐onset pre‐eclampsia
Fetuses
first‐trimester screening
Health care
Medical screening
Morbidity
Predictions
Preeclampsia
Risk
Womens health
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Summary:ABSTRACT Objective Pre‐eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality. A first‐trimester screening algorithm predicting the risk of early‐onset PE has been developed and validated. Early prediction coupled with initiation of aspirin at 11–13 weeks in women identified as high risk is effective at reducing the prevalence of early‐onset PE. The aim of this study was to evaluate the cost‐effectiveness of this first‐trimester screening program coupled with early use of low‐dose aspirin in women at high risk of developing early‐onset PE, in comparison to current practice in Canada. Methods A decision analysis was performed based on a theoretical population of 387 516 live births in Canada in 1 year. The clinical and financial impact of early preventative screening using the Fetal Medicine Foundation algorithm for prediction of early‐onset PE coupled with early (
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.19076