Medicine based evidence and personalized care of patients

Background For the past 70‐ years patient care has been dominated by Evidence Based Medicine (EBM) with its emphasis on Randomized Controlled Trials (RCTs) and clinical guidelines to standardize medical decision‐making. Methods Critical assessment of the literature and analyses of the arguments that...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical investigation 2018-07, Vol.48 (7), p.e12945-n/a
Main Authors: Horwitz, Ralph I., Charlson, Mary E., Singer, Burton H.
Format: Article
Language:English
Subjects:
Biographies
Clinical Decision-Making
clinical guidelines
Clinical trials
Decision analysis
Decision making
Electronic health records
Electronic medical records
Evidence-Based Medicine
Health risks
Humans
Medical treatment
Medicine
medicine based evidence
Patients
Practice Guidelines as Topic
Precision Medicine
randomized controlled trials
Randomized Controlled Trials as Topic
Standardization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background For the past 70‐ years patient care has been dominated by Evidence Based Medicine (EBM) with its emphasis on Randomized Controlled Trials (RCTs) and clinical guidelines to standardize medical decision‐making. Methods Critical assessment of the literature and analyses of the arguments that favor patient care based primarily on individual variability in disease risk or treatment response versus emphasis on group standardization. Results Medicine Based Evidence (MBE) is used to guide decision making for an individual patient at hand by profiling the clinical features (biology) and life experience (biography) of the patient and then finding approximate matches to the patient in a clinical library of patients assembled from diverse sources (RCTs, cohorts, registries, electronic health records and more). Conclusion Medicine is transitioning from population based model of clinical care that relies on average results from RCTs to an individual‐based model of “personalized” medicine. For individualized care of the patient at hand, MBE is the preferred scientific strategy to generate evidence for patient care.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12945