Recent developments in chromatographic purification of biopharmaceuticals

Over the last several decades, researchers have time and again proposed use of non-chromatographic methods for processing of biotherapeutic products. However, chromatography continues to be the backbone of downstream processing, particularly at process scale. There are many reasons for this, critica...

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Bibliographic Details
Published in:Biotechnology letters 2018-06, Vol.40 (6), p.895-905
Main Authors: Rathore, Anurag S., Kumar, Devashish, Kateja, Nikhil
Format: Article
Language:English
Subjects:
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biopharmaceuticals
Biotechnology
Chromatography
Life Sciences
Microbiology
Purification
Review
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Summary:Over the last several decades, researchers have time and again proposed use of non-chromatographic methods for processing of biotherapeutic products. However, chromatography continues to be the backbone of downstream processing, particularly at process scale. There are many reasons for this, critical ones being the unparalleled scalability, robustness, and selectivity that process chromatography offers over its peers. It is no surprise then that process chromatography has been a topic of major developments in resin matrix, ligand chemistry, modalities, high throughput process development, process modelling, and approaches for control. In this review, we attempt to summarize major developments in the above-mentioned areas. Greater significance has been given to advancements in the last 5 years (2013–2017).
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-018-2552-1