Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades

[Display omitted] Appropriate selection of excipient grade during tablet formulation development depends on thorough knowledge in their compaction and flow properties. Each chemically unique pharmaceutical excipient is usually available in several commercial grades that are widely different in powde...

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Bibliographic Details
Published in:International journal of pharmaceutics 2018-07, Vol.546 (1-2), p.39-49
Main Authors: Paul, Shubhajit, Chang, Shao-Yu, Dun, Jiangnan, Sun, Wei-Jhe, Wang, Kunlin, Tajarobi, Pirjo, Boissier, Catherine, Sun, Changquan Calvin
Format: Article
Language:English
Subjects:
Direct compression
Lactose
Mannitol
Powder flow
Principal component analysis
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Summary:[Display omitted] Appropriate selection of excipient grade during tablet formulation development depends on thorough knowledge in their compaction and flow properties. Each chemically unique pharmaceutical excipient is usually available in several commercial grades that are widely different in powder properties, which influence their performance for a specific formulation application. In this work, 11 grades of mannitol were systematically characterized, in terms of their particulate, flow and tableting properties, and compared against 5 grades of lactose. Principal component analysis (PCA) identified significant correlations among selected variables, such as particle size, surface area, flowability, wall friction, plasticity parameter, tensile strength, and tablet brittleness. PCA also revealed similar grades of the two excipients, which may be used to select replacement grade, if needed, based on similarity in their overall properties.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2018.04.058