Microstructural correlates of 3D steady‐state inhomogeneous magnetization transfer (ihMT) in the human brain white matter assessed by myelin water imaging and diffusion tensor imaging

Purpose To compare the recently introduced inhomogeneous magnetization transfer (ihMT) technique with more established MRI techniques including myelin water imaging (MWI) and diffusion tensor imaging (DTI), and to evaluate the microstructural attributes correlating with this new contrast method in t...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2018-12, Vol.80 (6), p.2402-2414
Main Authors: Ercan, Ece, Varma, Gopal, Mädler, Burkhard, Dimitrov, Ivan E., Pinho, Marco C., Xi, Yin, Wagner, Benjamin C., Davenport, Elizabeth M., Maldjian, Joseph A., Alsop, David C., Lenkinski, Robert E., Vinogradov, Elena
Format: Article
Language:English
Subjects:
Adult
Anisotropy
Brain
Brain - diagnostic imaging
Brain Mapping - methods
Coefficient of variation
Computer Simulation
Correlation
Dependence
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Diffusivity
DTI
Eigenvectors
Female
Healthy Volunteers
Humans
ihMT
Image Processing, Computer-Assisted
Imaging, Three-Dimensional - methods
Magnetic fields
Magnetic resonance imaging
Magnetics
Magnetization
Male
Mathematical analysis
Medical imaging
MWI
Myelin
myelin imaging
Myelin Sheath - chemistry
Neuroimaging
Pattern Recognition, Automated
Software
Substantia alba
Tensors
Water
White Matter - diagnostic imaging
white matter microstructure
Young Adult
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Summary:Purpose To compare the recently introduced inhomogeneous magnetization transfer (ihMT) technique with more established MRI techniques including myelin water imaging (MWI) and diffusion tensor imaging (DTI), and to evaluate the microstructural attributes correlating with this new contrast method in the human brain white matter. Methods Eight adult healthy volunteers underwent T1‐weighted, ihMT, MWI, and DTI imaging on a 3T human scanner. The ihMT ratio (ihMTR), myelin water fraction (MWF), fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) values were calculated from different white matter tracts. The angle (θ) between the directions of the principal eigenvector, as measured by DTI, and the main magnetic field was calculated for all voxels from various fiber tracts. The ihMTR was correlated with MWF and DTI metrics. Results A strong correlation was found between ihMTR and MWF (ρ = 0.77, P 
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.27211