Bleeding during and after dental extractions in patients with liver cirrhosis

Little is known about the prevention and management of acquired coagulopathies, such as those affecting cirrhotic patients. The objective of this analytic retrospective observational study was to evaluate patients on the liver transplant waiting list according to the following outcomes: (1) presence...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2018-12, Vol.47 (12), p.1543-1549
Main Authors: Medina, J.B., Andrade, N.S., de Paula Eduardo, F., Bezinelli, L., Franco, J.B., Gallottini, M., Braz-Silva, P.H., Ortega, K.L.
Format: Article
Language:English
Subjects:
blood coagulation
Brazil
cirrhosis
dental care for chronically ill
Dentistry
end-stage liver disease
Female
haemorrhage
Humans
International Normalized Ratio
intraoperative complications
Liver Cirrhosis - complications
Male
Middle Aged
Platelet Count
Postoperative Hemorrhage - prevention & control
Retrospective Studies
Tooth Extraction
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Summary:Little is known about the prevention and management of acquired coagulopathies, such as those affecting cirrhotic patients. The objective of this analytic retrospective observational study was to evaluate patients on the liver transplant waiting list according to the following outcomes: (1) presence of unusual intraoperative bleeding (>10min after routine haemostatic procedures); and (2) presence of postoperative haemorrhagic complications. The outcomes were analysed according to clinical and laboratory variables. A total of 190 visits were performed for extraction of 333 teeth (ranging from 1 to 9 teeth per visit), with platelet count ranging from 16,000 to 216,000 and international normalized ratio (INR) below 3. Twelve cases (6.31%) had unusual intraoperative bleeding and 12 had postoperative haemorrhagic complications. All the events were controlled by local measures. Intraoperative bleeding was associated with low count of platelets (P=0.026). However, this counting could explain only 16% (adjusted R2=0.16) of the cases of bleeding (P=0.44), meaning that platelet function changes might be involved. Our results show that cirrhotic patients presenting platelet count above 16,000 and INR below 3 need no previous blood transfusion, with local measures being enough to manage haemorrhagic events.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2018.04.007