An Examination of Blood Cell Membrane Potential as a Diagnostic Test of Attention Deficit Disorder in Children

Objective: To reexamine previous findings that reported that blood cells’ membrane potential ratios (MPRs™) differ between youth with ADHD and controls and to determine whether psychostimulants affect MPRs™. Method: Forty-four youth (ages 6-17) with ADHD (not currently taking psychostimulants; n = 2...

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Bibliographic Details
Published in:Journal of attention disorders 2021-01, Vol.25 (1), p.73-80
Main Authors: Stepanova, Ekaterina, Findling, Robert L., Kaplin, Dana, Frimpong, Bernice, Pikalova, Sofia, Young, Andrea S.
Format: Article
Language:English
Subjects:
Adolescent
Attention Deficit Disorder with Hyperactivity - diagnosis
Attention Deficit Disorder with Hyperactivity - drug therapy
Blood Cells
Central Nervous System Stimulants - therapeutic use
Child
Diagnostic Tests, Routine
Humans
Membrane Potentials
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Summary:Objective: To reexamine previous findings that reported that blood cells’ membrane potential ratios (MPRs™) differ between youth with ADHD and controls and to determine whether psychostimulants affect MPRs™. Method: Forty-four youth (ages 6-17) with ADHD (not currently taking psychostimulants; n = 24) and controls (n = 20) completed the Mini-International Neuropsychiatric Interview 7 (MINI 7) and a blood draw to determine MPR™. Youth with ADHD provided another blood draw 30 days after receiving psychostimulants. Results: MPR™ values of participants with ADHD who were not taking stimulants were not significantly different from those of the controls. MPR’s™ sensitivity was 79.2% and specificity 25.0%. Among youth with ADHD, there was a trending association between lower MPRs™ and taking stimulants (compared with baseline). Conclusion: Results neither replicate prior findings nor support MPRs’™ utility in diagnosing ADHD in youth. We identified possible MPR™ changes after participants with ADHD began stimulants. Further studies are needed to establish the clinical significance of this finding.
ISSN:1087-0547
1557-1246
DOI:10.1177/1087054718772169