Haploidentical stem cell transplantation: T cell depleted and repleted

Allogeneic hematopoietic stem cell transplantation (AHSCT), is a curative treatment option for many hematological diseases. Donor availability is the major limiting factor in the transplantation setting. More than half of the patients do not have a HLA fully matched related/unrelated donor but almos...

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Bibliographic Details
Published in:Transfusion and apheresis science 2018-04, Vol.57 (2), p.171-173
Main Authors: Gokgoz, Z., Arslan, O.
Format: Article
Language:English
Subjects:
Haploidentical transplantation
Health technology assessment
T cell deplete
T cell replete
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Summary:Allogeneic hematopoietic stem cell transplantation (AHSCT), is a curative treatment option for many hematological diseases. Donor availability is the major limiting factor in the transplantation setting. More than half of the patients do not have a HLA fully matched related/unrelated donor but almost all patients have an haploidentical donor. Haploidentical transplantion can be performed either as T cell depleted or repleted. Despite the promising results in T cell depletion methods, expensive T cell selection and the necessity for experienced staff seem to be the limiting factors. However, a T cell repleted haploidentical stem cell transplantation strategy is simple, cheap and has been preferred by different transplant centers worldwide.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2018.04.016