Ir(III)-Catalyzed Oxidative Annulation of Phenylglyoxylic Acids with Benzo[b]thiophenes

An Ir­(III)-catalyzed oxidative annulation of phenylglyoxylic acids with benzo­[b]­thiophenes for the construction of benzo­thieno­[3,2-c]­[2]­benzo­pyranones in one step is disclosed. Three C–H cleavages and C–C/C–O bond formations are involved in this reaction. This protocol features a relatively...

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Bibliographic Details
Published in:Organic letters 2018-05, Vol.20 (10), p.3001-3005
Main Authors: Wang, Zhigang, Yang, Mufan, Yang, Yudong
Format: Article
Language:English
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Summary:An Ir­(III)-catalyzed oxidative annulation of phenylglyoxylic acids with benzo­[b]­thiophenes for the construction of benzo­thieno­[3,2-c]­[2]­benzo­pyranones in one step is disclosed. Three C–H cleavages and C–C/C–O bond formations are involved in this reaction. This protocol features a relatively broad substrate scope, good functional group tolerance, good regioselectivities, mild reaction conditions, and scale-up synthesis.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01033