Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis

Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2008-10, Vol.106 (4), p.368-374
Main Authors: Tashima, Yoshihiko, Hamada, Hiroyuki, Okamoto, Masahiro, Hanai, Taizo
Format: Article
Language:English
Subjects:
Animals
APOPTOSE
APOPTOSIS
Biological and medical sciences
Biotechnology
CARCINOGENESE
CARCINOGENESIS
CELL CYCLE
Cell Cycle Proteins - metabolism
CELL DIFFERENTIATION
Cell Transformation, Neoplastic
CICLO CELULAR
CYCLE CELLULAIRE
Cyclin-Dependent Kinases - metabolism
DIFERENCIACION CELULAR
DIFFERENCIATION CELLULAIRE
Fundamental and applied biological sciences. Psychology
G1 Phase
G1/S phase
GENE
GENES
HOMEOSTASIE
HOMEOSTASIS
Humans
Kinetics
MAMIFEROS
mammalian cell cycle
MAMMALS
MAMMIFERE
MAP Kinase Signaling System
mathematical modeling
MATHEMATICAL MODELS
MODELE MATHEMATIQUE
MODELOS MATEMATICOS
Models, Biological
Models, Theoretical
Phosphorylation
S Phase
system analysis
system biology
Systems Biology
Time Factors
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Summary:Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.
ISSN:1389-1723
1347-4421
DOI:10.1263/jbb.106.368