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Synthesis, biodegradability and cytotoxicity of water-soluble isobutylchitosan
The objective of the present study was to improve the solubility of chitosan at neutral aqueous solution without altering its bioactivity. Through an alkylation reaction under mild conditions, isobutyl was introduced to chitosan to form isobutylchitosan, which showed a good solubility in neutral aqu...
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| Published in: | Carbohydrate polymers 2007-01, Vol.67 (1), p.40-45 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c436t-800e817bb8fe70c13d57fae2a5794f39ff8de82f68966f33a89b1f0a0ec3222f3 |
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| container_end_page | 45 |
| container_issue | 1 |
| container_start_page | 40 |
| container_title | Carbohydrate polymers |
| container_volume | 67 |
| creator | Li, Dong-Hong Liu, Liang-Ming Tian, Kun-Lun Liu, Jian-Chang Fan, Xiao-Qing |
| description | The objective of the present study was to improve the solubility of chitosan at neutral aqueous solution without altering its bioactivity. Through an alkylation reaction under mild conditions, isobutyl was introduced to chitosan to form isobutylchitosan, which showed a good solubility in neutral aqueous media resulting from the reduced crystallinity of the product. The structure of isobutylchitosan was characterized by IR,
1H NMR spectroscopy, and X-ray diffraction. The degradation of the product was evaluated in vivo using a mouse model, and the cytotoxicity of the product in L929 mouse fibroblasts was monitored using the MTT assay and the release of the cytosolic enzyme lactate dehydrogenase (LDH). It was found that the product exhibited the properties of improved biodegradability, increased MTT values and decreased LDH release. The results suggested that isobutylchitosan might be one of promising and safe biomaterial with potential applications. |
| doi_str_mv | 10.1016/j.carbpol.2006.04.022 |
| format | article |
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1H NMR spectroscopy, and X-ray diffraction. The degradation of the product was evaluated in vivo using a mouse model, and the cytotoxicity of the product in L929 mouse fibroblasts was monitored using the MTT assay and the release of the cytosolic enzyme lactate dehydrogenase (LDH). It was found that the product exhibited the properties of improved biodegradability, increased MTT values and decreased LDH release. The results suggested that isobutylchitosan might be one of promising and safe biomaterial with potential applications.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2006.04.022</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Biodegradability ; Cytotoxicity ; Exact sciences and technology ; Isobutylchitosan ; Natural polymers ; Physicochemistry of polymers ; Starch and polysaccharides ; Water solubility</subject><ispartof>Carbohydrate polymers, 2007-01, Vol.67 (1), p.40-45</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-800e817bb8fe70c13d57fae2a5794f39ff8de82f68966f33a89b1f0a0ec3222f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18400273$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Dong-Hong</creatorcontrib><creatorcontrib>Liu, Liang-Ming</creatorcontrib><creatorcontrib>Tian, Kun-Lun</creatorcontrib><creatorcontrib>Liu, Jian-Chang</creatorcontrib><creatorcontrib>Fan, Xiao-Qing</creatorcontrib><title>Synthesis, biodegradability and cytotoxicity of water-soluble isobutylchitosan</title><title>Carbohydrate polymers</title><description>The objective of the present study was to improve the solubility of chitosan at neutral aqueous solution without altering its bioactivity. Through an alkylation reaction under mild conditions, isobutyl was introduced to chitosan to form isobutylchitosan, which showed a good solubility in neutral aqueous media resulting from the reduced crystallinity of the product. The structure of isobutylchitosan was characterized by IR,
1H NMR spectroscopy, and X-ray diffraction. The degradation of the product was evaluated in vivo using a mouse model, and the cytotoxicity of the product in L929 mouse fibroblasts was monitored using the MTT assay and the release of the cytosolic enzyme lactate dehydrogenase (LDH). It was found that the product exhibited the properties of improved biodegradability, increased MTT values and decreased LDH release. The results suggested that isobutylchitosan might be one of promising and safe biomaterial with potential applications.</description><subject>Applied sciences</subject><subject>Biodegradability</subject><subject>Cytotoxicity</subject><subject>Exact sciences and technology</subject><subject>Isobutylchitosan</subject><subject>Natural polymers</subject><subject>Physicochemistry of polymers</subject><subject>Starch and polysaccharides</subject><subject>Water solubility</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkE1rGzEQhkVpoa7bn1DYS3PKbkYf1mpPJYQ0CYTk0OQstNpRLSOvXElOs_--a2zIMXMZGJ53hnkI-U6hoUDlxaaxJvW7GBoGIBsQDTD2gSyoaruaciE-kgVQIWolafuZfMl5A3NJCgvy8Hsayxqzz-dV7-OAf5IZTO-DL1NlxqGyU4klvnp7GERX_TMFU51j2PcBK59jvy9TsGtfYjbjV_LJmZDx26kvyfOv66er2_r-8ebu6vK-toLLUisAVLTte-WwBUv5sGqdQWZWbScc75xTAyrmpOqkdJwb1fXUgQG0nDHm-JKcHffuUvy7x1z01meLIZgR4z5rBpx1SqoZXB1Bm2LOCZ3eJb81adIU9MGe3uiTPX2wp0Ho2d6c-3E6YLI1wSUzWp_fwkoAsJbP3M8jh_O3Lx6TztbjaHHwCW3RQ_TvXPoPqAOKAg</recordid><startdate>20070102</startdate><enddate>20070102</enddate><creator>Li, Dong-Hong</creator><creator>Liu, Liang-Ming</creator><creator>Tian, Kun-Lun</creator><creator>Liu, Jian-Chang</creator><creator>Fan, Xiao-Qing</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20070102</creationdate><title>Synthesis, biodegradability and cytotoxicity of water-soluble isobutylchitosan</title><author>Li, Dong-Hong ; Liu, Liang-Ming ; Tian, Kun-Lun ; Liu, Jian-Chang ; Fan, Xiao-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-800e817bb8fe70c13d57fae2a5794f39ff8de82f68966f33a89b1f0a0ec3222f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>Biodegradability</topic><topic>Cytotoxicity</topic><topic>Exact sciences and technology</topic><topic>Isobutylchitosan</topic><topic>Natural polymers</topic><topic>Physicochemistry of polymers</topic><topic>Starch and polysaccharides</topic><topic>Water solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Dong-Hong</creatorcontrib><creatorcontrib>Liu, Liang-Ming</creatorcontrib><creatorcontrib>Tian, Kun-Lun</creatorcontrib><creatorcontrib>Liu, Jian-Chang</creatorcontrib><creatorcontrib>Fan, Xiao-Qing</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Dong-Hong</au><au>Liu, Liang-Ming</au><au>Tian, Kun-Lun</au><au>Liu, Jian-Chang</au><au>Fan, Xiao-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, biodegradability and cytotoxicity of water-soluble isobutylchitosan</atitle><jtitle>Carbohydrate polymers</jtitle><date>2007-01-02</date><risdate>2007</risdate><volume>67</volume><issue>1</issue><spage>40</spage><epage>45</epage><pages>40-45</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>The objective of the present study was to improve the solubility of chitosan at neutral aqueous solution without altering its bioactivity. Through an alkylation reaction under mild conditions, isobutyl was introduced to chitosan to form isobutylchitosan, which showed a good solubility in neutral aqueous media resulting from the reduced crystallinity of the product. The structure of isobutylchitosan was characterized by IR,
1H NMR spectroscopy, and X-ray diffraction. The degradation of the product was evaluated in vivo using a mouse model, and the cytotoxicity of the product in L929 mouse fibroblasts was monitored using the MTT assay and the release of the cytosolic enzyme lactate dehydrogenase (LDH). It was found that the product exhibited the properties of improved biodegradability, increased MTT values and decreased LDH release. The results suggested that isobutylchitosan might be one of promising and safe biomaterial with potential applications.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.carbpol.2006.04.022</doi><tpages>6</tpages></addata></record> |
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| ispartof | Carbohydrate polymers, 2007-01, Vol.67 (1), p.40-45 |
| issn | 0144-8617 1879-1344 |
| language | eng |
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| source | Elsevier |
| subjects | Applied sciences Biodegradability Cytotoxicity Exact sciences and technology Isobutylchitosan Natural polymers Physicochemistry of polymers Starch and polysaccharides Water solubility |
| title | Synthesis, biodegradability and cytotoxicity of water-soluble isobutylchitosan |
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