Preparation of androsta-1,4-diene-3,17-dione from sterols using Mycobacterium neoaurum VKPM Ac-1656 strain

A product of microbiological cleavage of the sterols side chain, androsta-1,4-diene-3,17-dione, is toxic for bacteria, in particular, actinobacteria of the genera Mycobacterium and Arthrobacter. Sterols were transformed into androsta-1,4-diene-3,17-dione by culturing the M. neoaurum VKPM Ac-1656 str...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2007-05, Vol.33 (3), p.354-358
Main Authors: Molchanova, M. A., Andryushina, V. A., Savinova, T. S., Stytsenko, T. S., Rodina, N. V., Voishvillo, N. E.
Format: Article
Language:English
Subjects:
Actinobacteria
Arthrobacter
Mycobacterium
Mycobacterium neoaurum
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Summary:A product of microbiological cleavage of the sterols side chain, androsta-1,4-diene-3,17-dione, is toxic for bacteria, in particular, actinobacteria of the genera Mycobacterium and Arthrobacter. Sterols were transformed into androsta-1,4-diene-3,17-dione by culturing the M. neoaurum VKPM Ac-1656 strain in a high yield, provided that a sorbent was used for elimination of contact between the bacterial cells and the product. Unlike the cholesterol side chain, the more branched chains of phytosterols were cleaved in the presence of M. neoaurum at a high rate only under turbulent stirring of the culture medium, which intensified the formation of hydrocarbonate ion from NaNI sub(3) in situ.
ISSN:1068-1620
1573-9163
1608-330X
DOI:10.1134/S1068162007030132