The Alcohol Dehydrogenase Isoenzyme as a Potential Marker of Pancreatitis

Human pancreas parenchyma contains various alcohol dehydrogenase (ADH) isoenzymes and also possesses aldehyde dehydrogenase (ALDH) activity. The altered activities of ADH and ALDH in damaged pancreatic tissue in the course of pancreatitis are reflected in the human serum. The aim of this study was t...

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Bibliographic Details
Published in:Anticancer research 2018-05, Vol.38 (5), p.3019-3024
Main Authors: Jelski, Wojciech, Piechota, Joanna, Orywal, Karolina, Szmitkowski, Maciej
Format: Article
Language:English
Subjects:
Alcohol
Alcohol dehydrogenase
Alcohols
Aldehyde dehydrogenase
Dehydrogenase
Dehydrogenases
Diagnostic systems
Isoenzymes
Measurement methods
Pancreas
Pancreatitis
Parenchyma
Patients
Photometry
Sampling methods
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Summary:Human pancreas parenchyma contains various alcohol dehydrogenase (ADH) isoenzymes and also possesses aldehyde dehydrogenase (ALDH) activity. The altered activities of ADH and ALDH in damaged pancreatic tissue in the course of pancreatitis are reflected in the human serum. The aim of this study was to investigate a potential role of ADH and ALDH as markers for acute (AP) and chronic pancreatitis (CP). Serum samples were collected for routine biochemical investigations from 75 patients suffering from acute pancreatitis and 70 patients with chronic pancreatitis. Fluorometric methods were used to measure the activity of class I and II ADH and ALDH activity. The total ADH activity and activity of class III and IV isoenzymes were measured by a photometric method. There was a significant increase in the activity of ADH III isoenzyme (15.06 mU/l and 14.62 mU/l vs. 11.82 mU/l; p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.12556