Correlation Between Disease Stage and the Presence of Viable Circulating Tumor Cells in Endometrial Cancer

The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the per...

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Bibliographic Details
Published in:Anticancer research 2018-05, Vol.38 (5), p.2983-2987
Main Authors: Kiss, Imrich, Kolostova, Katarina, Matkowski, Rafał, Jędryka, Marcin, Czekański, Andrzej, Pavlasek, Jiri, Bobek, Vladimir
Format: Article
Language:English
Subjects:
Blood circulation
Cancer
Endometrial cancer
Endometrium
Patients
Peripheral blood
Phenotypes
Sampling methods
Solid tumors
Surgery
Technology
Tumor cells
Tumors
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Summary:The presence of circulating tumor cells (CTCs) in the peripheral blood of patients with solid tumors is associated with a poor prognosis. However, there are limited data concerning the detection of CTCs in endometrial cancer (EC). The aim of this study was to evaluate the presence of CTCs in the peripheral blood of patients with EC. Peripheral blood samples from 92 patients who underwent a surgical procedure were evaluated using MetaCell® separation technology for CTCs. CTCs were detected in 69 (75%) patients with EC. CTCs were detected in a higher percentage of patients than in other studies. The results showed that the technology applied in this study can efficiently capture viable tumor cells in the blood that can be cultured while maintaining their original phenotype. This paper discusses the first successful culturing of human circulating endometrial cancer cells for further downstream functional and molecular characterization.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.12550