The Total Synthesis of Eleutherobin: A Surprise Ending

An “sp2–sp3 Stille coupling” of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a natural product exhibiting taxol‐like cytotoxic activity.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 1998-04, Vol.37 (6), p.789-792
Main Authors: Chen, Xiao-Tao, Zhou, Bishan, Bhattacharya, Samit K., Gutteridge, Clare E., Pettus, Thomas R. R., Danishefsky, Samuel J.
Format: Article
Language:English
Subjects:
Antitumor agents
Eleutherobin
Glycosylations
Stille coupling
Total synthesis
Online Access:Get full text
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Description
Summary:An “sp2–sp3 Stille coupling” of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a natural product exhibiting taxol‐like cytotoxic activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980403)37:6<789::AID-ANIE789>3.0.CO;2-3