New Tripodal, "Supercharged" Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap3 A Hydrolase

Methanetrisphosphonic acids provide a branch point for synthetic nucleotide analogues which can be exploited either to generate novel tripodal nucleotides or to incorporate additional negative charge into linear analogues relative to the parent nucleotide, as exemplified in the picture for ATP and d...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 1999-05, Vol.38 (9), p.1244-1247
Main Authors: Liu, Xiaohai, Brenner, Charles, Guranowski, Andrzej, Starzynska, Elzbieta, Blackburn, G Michael
Format: Article
Language:English
Online Access:Get full text
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Summary:Methanetrisphosphonic acids provide a branch point for synthetic nucleotide analogues which can be exploited either to generate novel tripodal nucleotides or to incorporate additional negative charge into linear analogues relative to the parent nucleotide, as exemplified in the picture for ATP and diadenosine tetraphosphate (Ap4 A). These compounds show valuable discriminatory behavior as competitive inhibitors for the tumor suppressor protein Fhit and a second Apn A pyrophosphohydrolase. X=H, Cl, F.
ISSN:1521-3773
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1244::AID-ANIE1244>3.0.CO;2-0