Selective Enhancement of the One-Electron Oxidation of Guanine by Base Pairing with Cytosine

The oxidation potential of guanine is lowered by 100 mV on selective hydrogen bonding to a cytosine residue. This has been established by examining the effects of the base pairing of guanine to other nucleosides on the rate constant of the electron transfer from guanine to the excited electron accep...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2000-12, Vol.39 (23), p.4327-4329
Main Authors: Kawai, Kiyohiko, Wata, Yasuharu, Ichinose, Nobuyuki, Majima, Tetsuro
Format: Article
Language:English
Subjects:
DNA oxidation
electron transfer
hydrogen bonds
nucleosides
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Summary:The oxidation potential of guanine is lowered by 100 mV on selective hydrogen bonding to a cytosine residue. This has been established by examining the effects of the base pairing of guanine to other nucleosides on the rate constant of the electron transfer from guanine to the excited electron acceptor molecule N,N′‐dibutylnaphthaladiimide (NDI, see scheme). An enhancement of the electron transfer was observed selectively for the G:C pair.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20001201)39:23<4327::AID-ANIE4327>3.0.CO;2-6