Testing Racemic Chiral Catalysts for Kinetic Resolution Potential

An even‐handed approach: by use of an enantiomerically enriched substrate and study of the changes in enantiomer ratio of substrate under pseudo zero‐order conditions, racemic catalysts may be employed to determine whether the enantiomerically pure catalyst would be effective for kinetic resolution...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2001-11, Vol.40 (22), p.4289-4291
Main Authors: Dominguez, Beatriz, Hodnett, Neil S., Lloyd-Jones, Guy C.
Format: Article
Language:English
Subjects:
allylation
asymmetric catalysis
kinetic resolution
palladium
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Summary:An even‐handed approach: by use of an enantiomerically enriched substrate and study of the changes in enantiomer ratio of substrate under pseudo zero‐order conditions, racemic catalysts may be employed to determine whether the enantiomerically pure catalyst would be effective for kinetic resolution of the racemic substrate (see scheme; E=CO2Me).
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011119)40:22<4289::AID-ANIE4289>3.0.CO;2-4