Anti-Rhizopus activity of tanzawaic acids produced by the hot spring-derived fungus Penicillium sp. BF-0005

A silkworm infection assay with the pathogenic fungus Rhizopus oryzae was established. Microbial culture broths were screened for anti- Rhizopus antibiotics using this assay. A new compound, tanzawaic acid R was isolated along with known and structurally related tanzawaic acids and arohynapene A fro...

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Bibliographic Details
Published in:Journal of antibiotics 2018-07, Vol.71 (7), p.626-632
Main Authors: Tominaga, Takehiro, Uchida, Ryuji, Koyama, Nobuhiro, Tomoda, Hiroshi
Format: Article
Language:English
Subjects:
631/154/1435/2417
631/326/22/1290
Acids
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Fungi
Hot springs
Life Sciences
Medicinal Chemistry
Microbiology
NMR
Nuclear magnetic resonance
Organic Chemistry
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Summary:A silkworm infection assay with the pathogenic fungus Rhizopus oryzae was established. Microbial culture broths were screened for anti- Rhizopus antibiotics using this assay. A new compound, tanzawaic acid R was isolated along with known and structurally related tanzawaic acids and arohynapene A from the culture broth of the hot spring-derived fungus Penicillium sp. BF-0005. The structure of tanzawaic acid R was elucidated by various spectroscopic data including 1D and 2D nuclear magnetic resonance spectroscopy. Tanzawaic acids A, B, C, and R and arohynapene A exhibited antifungal activity against R. oryzae . Tanzawaic acids A and B dose-dependently exerted therapeutic effects in the silkworm infection assay with R. oryzae .
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-018-0049-8