Resveratrol Protects Purkinje Neurons and Restores Muscle Activity in Rat Model of Cerebellar Ataxia

Cerebellar ataxia (CA) is regarded as a miscellaneous cluster of brain disorders related to the cerebellum. Resveratrol is a naturally occurring polyphenolic compound. Previous reports suggest that resveratrol confers neuroprotection in various animal models of brain damage. Indeed, we considered it...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2018-05, Vol.65 (1), p.35-42
Main Authors: Ghorbani, Zeynab, Farahani, Reza Mastery, Aliaghaei, Abbas, Khodagholi, Fariba, Meftahi, Gholam houssein, Danyali, Samira, Abdollahifar, Mohammad Amin, Daftari, Mahtab, Boroujeni, Mahdi Eskandarian, Sadeghi, Yousef
Format: Article
Language:English
Subjects:
Animal models
Apoptosis
Ataxia
Biomedical and Life Sciences
Biomedicine
Brain
Brain damage
Brain injury
Cell Biology
Cerebellar ataxia
Cerebellum
Electromyography
Motor task performance
Muscle function
Muscles
Neurochemistry
Neurology
Neurons
Neuroprotection
Neurosciences
Proteomics
Purkinje cells
Rats
Resveratrol
Rodents
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Summary:Cerebellar ataxia (CA) is regarded as a miscellaneous cluster of brain disorders related to the cerebellum. Resveratrol is a naturally occurring polyphenolic compound. Previous reports suggest that resveratrol confers neuroprotection in various animal models of brain damage. Indeed, we considered it invaluable to investigate whether a treatment with resveratrol has a therapeutic role against CA induced by 3-acetylpyridine (3-AP) in rats. In addition, no investigation has examined neuroprotective effect of resveratrol in rat model of CA. Initially, 3-AP administration generated CA rat models followed by intraperitoneal injection with resveratrol. Then, motor performance and muscle electromyography (EMG) activity were assessed. Moreover, the anti-apoptotic role of resveratrol in CA and its relationship to protection of Purkinje cells were explored. According to what we have found, resveratrol administration improved the muscle activity and movement coordination in 3-AP-lesioned rats. Also under resveratrol treatment, the total number of the Purkinje neurons increased whereas a reduction in apoptotic bodies was observed. In conclusion, post-treatment with resveratrol evidently ameliorated motor performance as well as muscle activity accompanied by a protection of Purkinje cells in ataxic rats.
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-018-1065-7