Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study

• Published in: Journal of human hypertension 2018-07, Vol.32 (7), p.487-493
• Main Authors: Kasiakogias, Alexandros, Tsioufis, Costas, Dimitriadis, Kyriakos, Konstantinidis, Dimitrios, Koumelli, Areti, Leontsinis, Ioannis, Andrikou, Eirini, Vogiatzakis, Nikos, Marinaki, Smaragdi, Petras, Dimitrios, Fragoulis, Christos, Konstantinou, Konstantinos, Papademetriou, Vasilios, Tousoulis, Dimitrios
• Format: Article
• Language: English
• Subjects: 692/699/75/243; 692/700/1750; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Coronary artery disease; Development and progression; Diagnosis; Epidemiology; Health Administration; Health risk assessment; Heart diseases; Hypertension; Medicine; Medicine & Public Health; Morbidity; Prognosis; Public Health; Risk factors
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/s41371-018-0065-y

Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP