Metabolic engineering of Escherichia coli for the production of isoprenoids

Metabolic engineering is the practice of using directed genetic manipulations to rewire cellular metabolism primarily with the aim to transform the organism into a single-celled chemical factory. Using biological processes, we can produce more complex chemicals in a more sustainable way. This is par...

Full description

Saved in:
Bibliographic Details
Published in:FEMS microbiology letters 2018-05, Vol.365 (10)
Main Authors: Ward, Valerie C A, Chatzivasileiou, Alkiviadis O, Stephanopoulos, Gregory
Format: Article
Language:English
Subjects:
Biological activity
Chemical plants
Chemical synthesis
Chemicals
E coli
Escherichia coli
Escherichia coli - genetics
Escherichia coli - growth & development
Escherichia coli - metabolism
Industrial Microbiology
Metabolic Engineering
Metabolism
Microbiology
Terpenes
Terpenes - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic engineering is the practice of using directed genetic manipulations to rewire cellular metabolism primarily with the aim to transform the organism into a single-celled chemical factory. Using biological processes, we can produce more complex chemicals in a more sustainable way. This is particularly important for chemicals which are hard to synthesize using traditional chemistry. However, cells have evolved for growth and must be engineered to produce a single chemical at commercially viable levels. This review focuses on the strategies used to rewire cellular metabolism to produce chemicals using isoprenoid production in Escherichia coli as an example that illustrates many of the challenges faced in metabolic engineering.
ISSN:1574-6968
0378-1097
1574-6968
DOI:10.1093/femsle/fny079