Diversity-Based Organic Synthesis in the Era of Genomics and Proteomics

Is the game over or has it just begun? The technical advances related to genomics and proteomics research have provided the scientific community with large sets of sequence‐level genetic information with enormous potential for identification of new drug targets. Gene expression and genome‐wide gene...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2001-01, Vol.40 (2), p.339-346
Main Authors: Arya, Prabhat, Chou, Doug T. H., Baek, Myung-Gi
Format: Article
Language:English
Subjects:
combinatorial chemistry
heterocycles
molecular diversity
natural products
solid-phase synthesis
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Summary:Is the game over or has it just begun? The technical advances related to genomics and proteomics research have provided the scientific community with large sets of sequence‐level genetic information with enormous potential for identification of new drug targets. Gene expression and genome‐wide gene sequencing have been successfully accomplished. What is the next step? What will be done with this information? Challenges faced are to identify genes or proteins of interest and to determine the functions of a given gene or protein that we only know at the sequence level at the moment.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20010119)40:2<339::AID-ANIE339>3.0.CO;2-J