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Salivary Function and Oral Health Problems in Crohn's Disease Patients
Abstract Background In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in con...
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Published in: | Inflammatory bowel diseases 2018-05, Vol.24 (6), p.1361-1367 |
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creator | de Vries, Silvia A G Tan, Christopher X W Bouma, Gerd Forouzanfar, Tim Brand, Henk S de Boer, Nanne K |
description | Abstract
Background
In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.
Methods
The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).
Results
Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.
Conclusions
Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients.
10.1093/ibd/izy017_video1
izy017.video1
5776803023001 |
doi_str_mv | 10.1093/ibd/izy017 |
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Background
In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.
Methods
The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).
Results
Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.
Conclusions
Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients.
10.1093/ibd/izy017_video1
izy017.video1
5776803023001</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izy017</identifier><identifier>PMID: 29718221</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Amylases ; Biochemistry ; Causes of ; Complications and side effects ; Containers ; Crohn Disease - complications ; Crohn Disease - physiopathology ; Crohn's disease ; Dental Caries - epidemiology ; Female ; Gastrointestinal diseases ; Humans ; Male ; Middle Aged ; Mucin-5B - metabolism ; Netherlands ; Oral Health ; Oral Ulcer - epidemiology ; Periodontal diseases ; Quality of Life ; Risk factors ; Saliva - metabolism ; Salivary Glands - physiopathology ; Secretory Rate ; Surveys and Questionnaires ; Tertiary Care Centers ; Tooth diseases ; Ulcers ; Xerostomia ; Xerostomia - etiology ; Young Adult</subject><ispartof>Inflammatory bowel diseases, 2018-05, Vol.24 (6), p.1361-1367</ispartof><rights>2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018</rights><rights>COPYRIGHT 2018 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</citedby><cites>FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29718221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Vries, Silvia A G</creatorcontrib><creatorcontrib>Tan, Christopher X W</creatorcontrib><creatorcontrib>Bouma, Gerd</creatorcontrib><creatorcontrib>Forouzanfar, Tim</creatorcontrib><creatorcontrib>Brand, Henk S</creatorcontrib><creatorcontrib>de Boer, Nanne K</creatorcontrib><title>Salivary Function and Oral Health Problems in Crohn's Disease Patients</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract
Background
In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.
Methods
The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).
Results
Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.
Conclusions
Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients.
10.1093/ibd/izy017_video1
izy017.video1
5776803023001</description><subject>Adult</subject><subject>Amylases</subject><subject>Biochemistry</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Containers</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - physiopathology</subject><subject>Crohn's disease</subject><subject>Dental Caries - epidemiology</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucin-5B - metabolism</subject><subject>Netherlands</subject><subject>Oral Health</subject><subject>Oral Ulcer - epidemiology</subject><subject>Periodontal diseases</subject><subject>Quality of Life</subject><subject>Risk factors</subject><subject>Saliva - metabolism</subject><subject>Salivary Glands - physiopathology</subject><subject>Secretory Rate</subject><subject>Surveys and Questionnaires</subject><subject>Tertiary Care Centers</subject><subject>Tooth diseases</subject><subject>Ulcers</subject><subject>Xerostomia</subject><subject>Xerostomia - etiology</subject><subject>Young Adult</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kV9rFTEQxYMo9o---AEkIFIRts0k2U3yWG57rVBoQX0OySZrI7vJNdkV6qc3l61Cocg8zDD8zmGYg9AbIKdAFDsL1p2F3_cExDN0CC3rGi45f15nImRDlJIH6KiUH4TQWuolOqBKgKQUDtH2ixnDL5Pv8XaJ_RxSxCY6fJPNiK-8Gec7fJuTHf1UcIh4k9NdPCn4IhRvise3Zg4-zuUVejGYsfjXD_0Yfdteft1cNdc3nz5vzq-bnrdkbgC447IH0RLRmaG1TAnvpKwTMAeu6wdFOzAeOFjLrINBMCqsbWlLJXfsGH1YfXc5_Vx8mfUUSu_H0USflqIpYYwp0klZ0Xcr-t2MXoc4pDmbfo_r81YxzkCoPXX6BFXL-Sn0Kfoh1P0jwcdV0OdUSvaD3uUw1QdqIHofh65x6DWOCr99OHexk3f_0L__r8D7FUjL7n9GfwDSCZBO</recordid><startdate>20180518</startdate><enddate>20180518</enddate><creator>de Vries, Silvia A G</creator><creator>Tan, Christopher X W</creator><creator>Bouma, Gerd</creator><creator>Forouzanfar, Tim</creator><creator>Brand, Henk S</creator><creator>de Boer, Nanne K</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180518</creationdate><title>Salivary Function and Oral Health Problems in Crohn's Disease Patients</title><author>de Vries, Silvia A G ; Tan, Christopher X W ; Bouma, Gerd ; Forouzanfar, Tim ; Brand, Henk S ; de Boer, Nanne K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Amylases</topic><topic>Biochemistry</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Containers</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - physiopathology</topic><topic>Crohn's disease</topic><topic>Dental Caries - epidemiology</topic><topic>Female</topic><topic>Gastrointestinal diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucin-5B - metabolism</topic><topic>Netherlands</topic><topic>Oral Health</topic><topic>Oral Ulcer - epidemiology</topic><topic>Periodontal diseases</topic><topic>Quality of Life</topic><topic>Risk factors</topic><topic>Saliva - metabolism</topic><topic>Salivary Glands - physiopathology</topic><topic>Secretory Rate</topic><topic>Surveys and Questionnaires</topic><topic>Tertiary Care Centers</topic><topic>Tooth diseases</topic><topic>Ulcers</topic><topic>Xerostomia</topic><topic>Xerostomia - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Vries, Silvia A G</creatorcontrib><creatorcontrib>Tan, Christopher X W</creatorcontrib><creatorcontrib>Bouma, Gerd</creatorcontrib><creatorcontrib>Forouzanfar, Tim</creatorcontrib><creatorcontrib>Brand, Henk S</creatorcontrib><creatorcontrib>de Boer, Nanne K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Vries, Silvia A G</au><au>Tan, Christopher X W</au><au>Bouma, Gerd</au><au>Forouzanfar, Tim</au><au>Brand, Henk S</au><au>de Boer, Nanne K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary Function and Oral Health Problems in Crohn's Disease Patients</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2018-05-18</date><risdate>2018</risdate><volume>24</volume><issue>6</issue><spage>1361</spage><epage>1367</epage><pages>1361-1367</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract
Background
In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied.
Methods
The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9).
Results
Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population.
Conclusions
Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients.
10.1093/ibd/izy017_video1
izy017.video1
5776803023001</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29718221</pmid><doi>10.1093/ibd/izy017</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Amylases Biochemistry Causes of Complications and side effects Containers Crohn Disease - complications Crohn Disease - physiopathology Crohn's disease Dental Caries - epidemiology Female Gastrointestinal diseases Humans Male Middle Aged Mucin-5B - metabolism Netherlands Oral Health Oral Ulcer - epidemiology Periodontal diseases Quality of Life Risk factors Saliva - metabolism Salivary Glands - physiopathology Secretory Rate Surveys and Questionnaires Tertiary Care Centers Tooth diseases Ulcers Xerostomia Xerostomia - etiology Young Adult |
title | Salivary Function and Oral Health Problems in Crohn's Disease Patients |
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