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Salivary Function and Oral Health Problems in Crohn's Disease Patients

Abstract Background In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in con...

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Published in:Inflammatory bowel diseases 2018-05, Vol.24 (6), p.1361-1367
Main Authors: de Vries, Silvia A G, Tan, Christopher X W, Bouma, Gerd, Forouzanfar, Tim, Brand, Henk S, de Boer, Nanne K
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container_title Inflammatory bowel diseases
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creator de Vries, Silvia A G
Tan, Christopher X W
Bouma, Gerd
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de Boer, Nanne K
description Abstract Background In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied. Methods The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9). Results Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population. Conclusions Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1 izy017.video1 5776803023001
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The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied. Methods The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9). Results Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population. Conclusions Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1 izy017.video1 5776803023001</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izy017</identifier><identifier>PMID: 29718221</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Amylases ; Biochemistry ; Causes of ; Complications and side effects ; Containers ; Crohn Disease - complications ; Crohn Disease - physiopathology ; Crohn's disease ; Dental Caries - epidemiology ; Female ; Gastrointestinal diseases ; Humans ; Male ; Middle Aged ; Mucin-5B - metabolism ; Netherlands ; Oral Health ; Oral Ulcer - epidemiology ; Periodontal diseases ; Quality of Life ; Risk factors ; Saliva - metabolism ; Salivary Glands - physiopathology ; Secretory Rate ; Surveys and Questionnaires ; Tertiary Care Centers ; Tooth diseases ; Ulcers ; Xerostomia ; Xerostomia - etiology ; Young Adult</subject><ispartof>Inflammatory bowel diseases, 2018-05, Vol.24 (6), p.1361-1367</ispartof><rights>2018 Crohn's &amp; Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018</rights><rights>COPYRIGHT 2018 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</citedby><cites>FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29718221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Vries, Silvia A G</creatorcontrib><creatorcontrib>Tan, Christopher X W</creatorcontrib><creatorcontrib>Bouma, Gerd</creatorcontrib><creatorcontrib>Forouzanfar, Tim</creatorcontrib><creatorcontrib>Brand, Henk S</creatorcontrib><creatorcontrib>de Boer, Nanne K</creatorcontrib><title>Salivary Function and Oral Health Problems in Crohn's Disease Patients</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract Background In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied. Methods The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9). Results Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population. Conclusions Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1 izy017.video1 5776803023001</description><subject>Adult</subject><subject>Amylases</subject><subject>Biochemistry</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Containers</subject><subject>Crohn Disease - complications</subject><subject>Crohn Disease - physiopathology</subject><subject>Crohn's disease</subject><subject>Dental Caries - epidemiology</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucin-5B - metabolism</subject><subject>Netherlands</subject><subject>Oral Health</subject><subject>Oral Ulcer - epidemiology</subject><subject>Periodontal diseases</subject><subject>Quality of Life</subject><subject>Risk factors</subject><subject>Saliva - metabolism</subject><subject>Salivary Glands - physiopathology</subject><subject>Secretory Rate</subject><subject>Surveys and Questionnaires</subject><subject>Tertiary Care Centers</subject><subject>Tooth diseases</subject><subject>Ulcers</subject><subject>Xerostomia</subject><subject>Xerostomia - etiology</subject><subject>Young Adult</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kV9rFTEQxYMo9o---AEkIFIRts0k2U3yWG57rVBoQX0OySZrI7vJNdkV6qc3l61Cocg8zDD8zmGYg9AbIKdAFDsL1p2F3_cExDN0CC3rGi45f15nImRDlJIH6KiUH4TQWuolOqBKgKQUDtH2ixnDL5Pv8XaJ_RxSxCY6fJPNiK-8Gec7fJuTHf1UcIh4k9NdPCn4IhRvise3Zg4-zuUVejGYsfjXD_0Yfdteft1cNdc3nz5vzq-bnrdkbgC447IH0RLRmaG1TAnvpKwTMAeu6wdFOzAeOFjLrINBMCqsbWlLJXfsGH1YfXc5_Vx8mfUUSu_H0USflqIpYYwp0klZ0Xcr-t2MXoc4pDmbfo_r81YxzkCoPXX6BFXL-Sn0Kfoh1P0jwcdV0OdUSvaD3uUw1QdqIHofh65x6DWOCr99OHexk3f_0L__r8D7FUjL7n9GfwDSCZBO</recordid><startdate>20180518</startdate><enddate>20180518</enddate><creator>de Vries, Silvia A G</creator><creator>Tan, Christopher X W</creator><creator>Bouma, Gerd</creator><creator>Forouzanfar, Tim</creator><creator>Brand, Henk S</creator><creator>de Boer, Nanne K</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180518</creationdate><title>Salivary Function and Oral Health Problems in Crohn's Disease Patients</title><author>de Vries, Silvia A G ; Tan, Christopher X W ; Bouma, Gerd ; Forouzanfar, Tim ; Brand, Henk S ; de Boer, Nanne K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-114d48c175076af5b397ed88f5b13d1d6cf9261ae141bb3bd1f7327bb525284d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Amylases</topic><topic>Biochemistry</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Containers</topic><topic>Crohn Disease - complications</topic><topic>Crohn Disease - physiopathology</topic><topic>Crohn's disease</topic><topic>Dental Caries - epidemiology</topic><topic>Female</topic><topic>Gastrointestinal diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucin-5B - metabolism</topic><topic>Netherlands</topic><topic>Oral Health</topic><topic>Oral Ulcer - epidemiology</topic><topic>Periodontal diseases</topic><topic>Quality of Life</topic><topic>Risk factors</topic><topic>Saliva - metabolism</topic><topic>Salivary Glands - physiopathology</topic><topic>Secretory Rate</topic><topic>Surveys and Questionnaires</topic><topic>Tertiary Care Centers</topic><topic>Tooth diseases</topic><topic>Ulcers</topic><topic>Xerostomia</topic><topic>Xerostomia - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Vries, Silvia A G</creatorcontrib><creatorcontrib>Tan, Christopher X W</creatorcontrib><creatorcontrib>Bouma, Gerd</creatorcontrib><creatorcontrib>Forouzanfar, Tim</creatorcontrib><creatorcontrib>Brand, Henk S</creatorcontrib><creatorcontrib>de Boer, Nanne K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Vries, Silvia A G</au><au>Tan, Christopher X W</au><au>Bouma, Gerd</au><au>Forouzanfar, Tim</au><au>Brand, Henk S</au><au>de Boer, Nanne K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary Function and Oral Health Problems in Crohn's Disease Patients</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2018-05-18</date><risdate>2018</risdate><volume>24</volume><issue>6</issue><spage>1361</spage><epage>1367</epage><pages>1361-1367</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract Background In Crohn's disease (CD) patients, many oral complaints have been reported. The aim of this study was to determine whether salivary function is contributing to reduced oral health in CD. Oral and dental complaints in patients were explored. The prevalence of xerostomia in conjunction with salivary flow rates and biochemical saliva composition was studied. Methods The Xerostomia Inventory score (XI-score), the salivary flow rates, the concentrations of salivary amylase and mucin 5B, and the type of oral and dental complaints were evaluated. These outcomes were stratified by disease activity, using the Harvey Bradshaw Index (HBI) and the Inflammatory Bowel Disease Questionnaire (IBDQ-9). Results Fifty-three CD patients in a Dutch tertiary referral hospital were included. Of the patients evaluated, 9.4% had hyposalivation under resting conditions, and 28.3% had hyposalivation under chewing stimulated conditions. Saliva secretion rates were not correlated to XI-scores. Median XI-score was 25 (11-45). XI-scores were correlated to the IBDQ scores (r = −0.352, P = 0.010). Salivary mucin 5B was correlated to disease activity (r = 0.295, P = 0.04). Regarding the number of oral complaints, a correlation with disease activity (HBI r = 0.349, P = 0.011) and experienced xerostomia (r = −0.554, P = 0.000) was observed. Oral and dental problems like oral ulcers (37.7%) and cavities (46%) occurred more frequently in CD patients, especially when compared with a non-IBD population. Conclusions Oral and dental complaints are common in CD patients. Xerostomia is correlated with disease activity-associated quality of life and with the number of oral and dental complaints. Changes in salivary function may contribute to reduced oral health in CD patients. 10.1093/ibd/izy017_video1 izy017.video1 5776803023001</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29718221</pmid><doi>10.1093/ibd/izy017</doi><tpages>7</tpages></addata></record>
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source Oxford Journals Online
subjects Adult
Amylases
Biochemistry
Causes of
Complications and side effects
Containers
Crohn Disease - complications
Crohn Disease - physiopathology
Crohn's disease
Dental Caries - epidemiology
Female
Gastrointestinal diseases
Humans
Male
Middle Aged
Mucin-5B - metabolism
Netherlands
Oral Health
Oral Ulcer - epidemiology
Periodontal diseases
Quality of Life
Risk factors
Saliva - metabolism
Salivary Glands - physiopathology
Secretory Rate
Surveys and Questionnaires
Tertiary Care Centers
Tooth diseases
Ulcers
Xerostomia
Xerostomia - etiology
Young Adult
title Salivary Function and Oral Health Problems in Crohn's Disease Patients
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