Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer

The objective of the present study was to investigate the effect of tamoxifen (Tam) loaded solid lipid nanoparticles (SLNs) on MCF7 Tam-resistant breast cancer cells (MCF7-TamR). Tam-SLNs were produced by the hot homogenization method. The characterization studies of Tam-SLNs demonstrated good physi...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2018-07, Vol.120, p.73-88
Main Authors: Guney Eskiler, Gamze, Cecener, Gulsah, Dikmen, Gokhan, Egeli, Unal, Tunca, Berrin
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Drug resistance
Solid lipid nanoparticles
Tamoxifen
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Summary:The objective of the present study was to investigate the effect of tamoxifen (Tam) loaded solid lipid nanoparticles (SLNs) on MCF7 Tam-resistant breast cancer cells (MCF7-TamR). Tam-SLNs were produced by the hot homogenization method. The characterization studies of Tam-SLNs demonstrated good physical stability with small particle size. The in vitro cytotoxicity results showed that Tam-SLNs enhanced the efficacy of Tam and reversed the acquired Tam resistance by inducing apoptosis, altering the expression levels of specific miRNA and the related apoptosis-associated target-genes in both MCF7 and MCF7-TamR cells without damaging the MCF10A control cells (p 
ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2018.04.040