Anti-Chemokine Therapy for Inflammatory Diseases

Chemokines are inflammatory proteins acting via G-protein coupled chemokine receptors that trigger different signaling pathways. Monocyte chemoattractant protein-1 (CCL2/MCP-1) and regulated on activation, normal T expressed and secreted (CCL5/RANTES) are the two major members of the CC chemokine be...

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Bibliographic Details
Published in:International Journal of Immunopathology and Pharmacology 2007-07, Vol.20 (3), p.447-453
Main Authors: Castellani, M.L., Bhattacharya, K., Tagen, M., Kempuraj, D., Perrella, A., De Lutiis, M., Boucher, W., Conti, P., Theoharides, T.C., Cerulli, G., Salini, V., Neri, G.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Chemokine CCL2 - antagonists & inhibitors
Chemokine CCL2 - immunology
Chemokine CCL5 - antagonists & inhibitors
Chemokine CCL5 - immunology
Chemokines - antagonists & inhibitors
Chemokines - immunology
Humans
Inflammation - drug therapy
Inflammation - immunology
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Summary:Chemokines are inflammatory proteins acting via G-protein coupled chemokine receptors that trigger different signaling pathways. Monocyte chemoattractant protein-1 (CCL2/MCP-1) and regulated on activation, normal T expressed and secreted (CCL5/RANTES) are the two major members of the CC chemokine beta subfamily. The roles of RANTES and MCP-1 are emerging in regulating the recruitment of inflammatory cells into tissue during inflammation. The inhibition of MCP-1 and RANTES with corresponding antibodies or other inhibitors may provide benefits in different clinical scenarios including cancer, inflammation, CNS disorders, parasitic disease, autoimmune and heart diseases. RANTES and MCP-1 may represent targets for diagnostic procedures and therapeutic intervention, and may be useful as a prognostic factor in the above diseases.
ISSN:0394-6320
2058-7384
DOI:10.1177/039463200702000303