SurePath® LBC improves the diagnostic accuracy of intrahepatic and hilar cholangiocarcinoma

Introduction The current study aimed to compare cytology using SurePath® (SP)‐LBC and biliary tissue histology (BTH) for the diagnosis of biliary disease. Methods Between January 2014 and December 2016, 57 patients underwent endoscopic retrograde cholangiopancreatography for the diagnosis of biliary...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2018-08, Vol.29 (4), p.349-354
Main Authors: Naito, Y., Kawahara, A., Okabe, Y., Ishida, Y., Sadashima, E., Murata, K., Takase, Y., Abe, H., Yamaguchi, T., Tanigawa, M., Mihara, Y., Kondo, R., Kusano, H., Nakayama, M., Shimamatsu, K., Yano, H., Akiba, J.
Format: Article
Language:English
Subjects:
Accuracy
Benign
Bile
bile duct
Biliary tract
Cholangiocarcinoma
Cytology
Diagnosis
Gallbladder diseases
hilar cholangiocarcinoma
intrahepatic cholangiocarcinoma
liquid‐based cytology
Malignancy
SurePath
Surgery
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Summary:Introduction The current study aimed to compare cytology using SurePath® (SP)‐LBC and biliary tissue histology (BTH) for the diagnosis of biliary disease. Methods Between January 2014 and December 2016, 57 patients underwent endoscopic retrograde cholangiopancreatography for the diagnosis of biliary disease. Biliary cytological samples were processed using SP‐LBC and subsequently BTH was performed. A final diagnosis was confirmed by surgery (23 malignant cases) and clinical follow‐up (34 benign and malignant cases): 18 extrahepatic cholangiocarcinoma; 17 intrahepatic/hilar cholangiocarcinoma (intra/H‐CC); eight other malignant disease; and 14 benign biliary disease. The diagnoses made using SP‐LBC and BTH were classified into four categories: (1) benign; (2) indeterminate; (3) suspicious for malignancy/malignant; and (4) inadequate. In addition, diagnostic accuracy was compared between SP‐LBC and BTH. Results Although 23% (13/57) of BTH samples were classified as inadequate, all SP‐LBC cases were classified as adequate. Among 43 malignant cases, 11 normal, four indeterminate and 28 suspicious for malignancy/malignant were found using SP‐LBC (26%, 9% and 65%, respectively), in contrast to 10 inadequate, nine normal, 10 indeterminate and 14 suspicious for malignancy/malignant observed using BTH (23%, 21%, 23%, and 33%, respectively). The identification of malignant cells was strikingly different between SP‐LBC and BTH. Furthermore, limited to intra/H‐CC, accuracy was significantly higher using SP‐LBC than using BTH (P 
ISSN:0956-5507
1365-2303
DOI:10.1111/cyt.12565