The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus

Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other...

Full description

Saved in:
Bibliographic Details
Published in:International urology and nephrology 2018-08, Vol.50 (8), p.1453-1466
Main Authors: Kanbay, Mehmet, Onal, Emine M., Afsar, Baris, Dagel, Tuncay, Yerlikaya, Aslihan, Covic, Adrian, Vaziri, Nosratola D.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Chronic illnesses
Diabetes
Diabetes Mellitus - microbiology
Dysbiosis
Gastrointestinal Microbiome
Glucagon
Humans
Hypertension
Hypertension - microbiology
Inflammation
Inflammation - complications
Intestinal microflora
Kidney - physiopathology
Kidney diseases
Medicine
Medicine & Public Health
Metabolism
Microbiomes
Microbiota
Nephrology
Nephrology - Review
Pathogenesis
Peptides
Probiotics - therapeutic use
Proteinuria - microbiology
Renal Insufficiency, Chronic - microbiology
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD. The gut microbiota closely interacts with the inflammatory, renal, cardiovascular, and endocrine systems via metabolic, humoral, and neural signaling pathways, events which can lead to chronic systemic inflammation, proteinuria, hypertension, diabetes, and kidney disease. Given the established role of the gut microbiota in the development and progression of CKD and its complications, favorable modification of the composition and function of the gut microbiome represents an appealing therapeutic target for prevention and treatment of CKD. This review provides an overview of the role of the gut microbial dysbiosis in the pathogenesis of the common causes of CKD including hypertension, diabetes, and proteinuria as well as progression of CKD.
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-018-1873-2