Association between polymorphisms in vitamin D receptor gene and adolescent idiopathic scoliosis: a meta-analysis

• Published in: European spine journal 2018-09, Vol.27 (9), p.2175-2183
• Main Authors: Dai, Jun, Lv, Zheng-tao, Huang, Jun-ming, Cheng, Peng, Fang, Huang, Chen, An-min
• Format: Article
• Language: English
• Subjects: Bone mineral density; Data processing; Genetic analysis; Medicine; Medicine & Public Health; Meta-analysis; Minority & ethnic groups; Neurosurgery; Original Article; Population studies; Scoliosis; Single-nucleotide polymorphism; Statistical analysis; Surgical Orthopedics; Vitamin D; Vitamin D receptors
• ISSN: 0940-6719; 1432-0932
• DOI: 10.1007/s00586-018-5614-0

Purpose This meta-analysis was performed to clarify whether the two single nucleotide polymorphisms ( ApaI and BsmI ) in vitamin D receptor (VDR) gene conferred susceptibility to adolescent idiopathic scoliosis (AIS). Methods A comprehensive literature search in five online databases (PubMed, EMBASE, ISI Web of Science, CNKI, and Wanfang) was performed to identify studies that analyzed the association between VDR gene polymorphisms and risk of AIS. Observational studies met the predetermined inclusion criteria were selected for meta-analysis. The most appropriate genetic model was identified using a genetic model-free approach. Meta-analysis was performed using RevMan 5.3 software. Results Five eligible studies were included in this meta-analysis, which involved a total of 717 cases and 554 controls. A statistically significant association was observed between BsmI polymorphism and AIS (OR 1.90, 95% CI 1.32, 2.62). In subgroup analysis by ethnicity, the association between BsmI polymorphism and AIS was significant in Asians (OR 2.06, 95% CI 1.56, 2.73) but not in Caucasians (OR 0.70, 95% CI 0.23, 2.19). However, the ApaI polymorphism was not associated with AIS. Moreover, no evidence of association between BMD and the two VDR gene polymorphisms was detected. Conclusions Meta-analysis of existing data suggested that BsmI was associated with increased risk of AIS in Asian populations. Nevertheless, further studies with rigorous design and more ethnic groups are encouraged to validate our findings. Graphical abstract These slides can be retrieved under Electronic Supplementary Material.