The correlation between striatal and cortical binding ratio of 11C-PiB-PET in amyloid-uptake-positive patients

Purpose In subjects with amyloid deposition, striatal accumulation of 11 C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer’s disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable...

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Bibliographic Details
Published in:Annals of nuclear medicine 2018-07, Vol.32 (6), p.398-403
Main Authors: Sauerbeck, Julia, Ishii, Kazunari, Hosokawa, Chisa, Kaida, Hayato, Scheiwein, Franziska T., Hanaoka, Kohei, Rominger, Axel, Brendel, Matthias, Bartenstein, Peter, Murakami, Takamichi
Format: Article
Language:English
Subjects:
Accumulation
Alzheimer's disease
Binding
Brain
Brodmann's area
Cognitive ability
Correlation analysis
Degeneration
Dementia disorders
Frontotemporal dementia
Imaging
Lewy bodies
Medicine
Medicine & Public Health
Neostriatum
Neurodegeneration
Nuclear Medicine
Occipital lobe
Original Article
Patients
Positron emission
Positron emission tomography
Prefrontal cortex
Radiology
Tomography
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Summary:Purpose In subjects with amyloid deposition, striatal accumulation of 11 C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer’s disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential ( BP ND ). Methods Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson’s disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BP ND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BP ND measures. Results There were highly significant correlations between striatal and prefrontal BP ND , with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BP ND values correlated with striatal BP ND values, with the exception of the occipital cortex with low correlation. Conclusion Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-018-1258-8