Soluble CD146 and B-type natriuretic peptide dissect overhydration into functional components of prognostic relevance in haemodialysis patients

Accurate volume status evaluation and differentiation of cardiac and non-cardiac components of overhydration (OH) are fundaments of optimal haemodialysis (HD) management. This study, by combining bioimpedance measurements, cardiovascular biomarkers and echocardiography, aimed at dissecting OH into i...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2018-11, Vol.33 (11), p.2035-2042
Main Authors: Arrigo, Mattia, Von Moos, Seraina, Gerritsen, Kerem, Sadoune, Malha, Tangvoraphonkchai, Kamonwan, Davenport, Andrew, Mebazaa, Alexandre, Segerer, Stephan, Cippà, Pietro E
Format: Article
Language:English
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Summary:Accurate volume status evaluation and differentiation of cardiac and non-cardiac components of overhydration (OH) are fundaments of optimal haemodialysis (HD) management. This study, by combining bioimpedance measurements, cardiovascular biomarkers and echocardiography, aimed at dissecting OH into its major functional components, and prospectively tested the association between cardiac and non-cardiac components of OH with mortality. In the first part, we validated soluble CD146 (sCD146) as a non-cardiac biomarker of systemic congestion in a cohort of 30 HD patients. In the second part, we performed a prospective 1-year follow-up study in an independent cohort of 144 HD patients. sCD146 incrementally increased after the short and long intervals after HD (+53 ng/mL, P = 0.006 and  +91 ng/mL, P 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfy113