Exhaled Nitric Oxide Levels After Specific Inahalatory Challenge Test in Subjects with Diagnosed Occupational Asthma

Objectives: Measuring exhaled nitric oxide (eNO) is a useful method for the assessment of bronchial inflammation in asthmatic subjects. The aim of the study was to evaluate the changes in eNO level in the subjects with suspected occupational asthma (OA) after a specific inhalation test (SIT) with oc...

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Bibliographic Details
Published in:International journal of occupational medicine and environmental health 2008-01, Vol.21 (3), p.219-225
Main Authors: Świerczyńska-Machura, Dominika, Krakowiak, Anna, Wiszniewska, Marta, Dudek, Wojciech, Walusiak, Jolanta, Pałczyński, Cezary
Format: Article
Language:English
Subjects:
Adult
Allergens - administration & dosage
Asthma - diagnosis
Asthma - immunology
Asthma - metabolism
Breath Tests - methods
Bronchial Provocation Tests - methods
Diagnostics
Exhalation
Female
Humans
Inhalation Exposure
Male
Middle Aged
Nitric Oxide - metabolism
Nitric oxides
Occupational asthma
Occupational Diseases - diagnosis
Occupational Diseases - immunology
Occupational Diseases - metabolism
Skin Tests
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Summary:Objectives: Measuring exhaled nitric oxide (eNO) is a useful method for the assessment of bronchial inflammation in asthmatic subjects. The aim of the study was to evaluate the changes in eNO level in the subjects with suspected occupational asthma (OA) after a specific inhalation test (SIT) with occupational agents. Materials and Methods: Forty two patients, including 17 farmers, 15 bakers and 10 health care workers had a physical examination, skin prick tests with common and occupational allergens, total serum IgE level, specific anti-allergen IgE determinations, spirometry and SIT. Also, morphological changes in induced sputum (ISP) and nasal lavage fluid (NLF) were analysed and eNO measurements were performed. Results: SIT revealed a significant increase in the proportion of eosinophils in NLF and in ISP in the cases with diagnosed OA. Moreover, these cases showed significantly increased eNO levels only 24 h after SIT, compared to the measurements before SIT. We also found a significant correlation between eNO level at 24 h after SIT and the percentage of eosinophils in NLF before, and 4 and 24 h after SIT, as well as in ISP before and 24 h after SIT in all subjects with diagnosed OA. Conclusion: The findings may confirm the usefulness of exhaled nitric oxide measurements for diagnosing OA.
ISSN:1232-1087
1896-494X
DOI:10.2478/v10001-008-0024-x