CpCo(III)-Catalyzed C–H Alkylation with Maleimides Using Weakly Coordinating Carbonyl Directing Groups

A novel protocol for ortho-C–H alkylation of aromatic and heteroaromatic ketones and esters under Cp*Co­(III) catalysis has been developed for the first time. The reaction proceeds through initial cyclometalation via weak chelation-assisted C–H bond activation, followed by coordination of activated...

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Bibliographic Details
Published in:Organic letters 2018-05, Vol.20 (10), p.2835-2838
Main Authors: Mandal, Rajib, Emayavaramban, Balakumar, Sundararaju, Basker
Format: Article
Language:English
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Summary:A novel protocol for ortho-C–H alkylation of aromatic and heteroaromatic ketones and esters under Cp*Co­(III) catalysis has been developed for the first time. The reaction proceeds through initial cyclometalation via weak chelation-assisted C–H bond activation, followed by coordination of activated alkene, insertion between Co–C, and protodemetalation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00761