Parastar insecticide induced changes in reproductive parameters and testicular oxidative stress biomarkers in Wistar male rats

Parastar is an insecticide formulation of lambda-cyhalothrin and imidacloprid, and it is largely used for crop production improvement in Santa, North West Region of Cameroon. This study aimed at evaluating the effects of Parastar on reproductive parameters and testicular oxidative stress in adult al...

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Bibliographic Details
Published in:Toxicology and industrial health 2018-07, Vol.34 (7), p.499-506
Main Authors: Nantia, Edouard Akono, Kada, Antoine S, Manfo, Faustin PT, Tangu, Nehemiah N, Mbifung, Kaghou M, Mbouobda, Desire H, Kenfack, Augustave
Format: Article
Language:English
Subjects:
Agricultural production
Biomarkers
Body weight
Catalase
Crop production
Cyhalothrin
Distilled water
Fertility
Glutathione
Imidacloprid
Insecticides
Oxidative stress
Parameters
Prostate
Rats
Rodents
Seminal vesicle
Sperm
Superoxide dismutase
Testes
Testosterone
Thiobarbituric acid
Water treatment
Weight reduction
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Summary:Parastar is an insecticide formulation of lambda-cyhalothrin and imidacloprid, and it is largely used for crop production improvement in Santa, North West Region of Cameroon. This study aimed at evaluating the effects of Parastar on reproductive parameters and testicular oxidative stress in adult albino Wistar male rats. Twenty rats (154 g ± 28 g) were divided into four groups of five animals each and treated daily with either distilled water (10 mL/kg), 1.25, 2.49 or 6.23 mg/kg of Parastar, respectively, for 35 days. After treatment, animal reproductive function was evaluated through fertility tests, sperm characteristics, testosterone levels and organ weights, while oxidative stress biomarkers were determined on testicular homogenates. Parastar administration resulted into increased seminal vesicle and prostate weights, while body weight remained unaffected. Parastar dose-dependently reduced sperm density and mobility, and the highest dose decreased serum testosterone levels. Parastar also modulated stress biomarkers with increased thiobarbituric acid reactive substances levels, decreased glutathione levels and inhibition of catalase and superoxide dismutase activities. In conclusion, Parastar negatively affected male reproductive function through alteration of testosterone levels, sperm parameters and induction of oxidative stress in rats.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233718761699