Circulating biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy assessed by cardiac magnetic resonance

Background: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. Objective: The aim of this study was to evaluate usefulness of var...

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Published in:Biomarkers 2018-10, Vol.23 (7), p.676-682
Main Authors: Gawor, Monika, Śpiewak, Mateusz, Kubik, Agata, Wróbel, Aleksandra, Lutyńska, Anna, Marczak, Magdalena, Grzybowski, Jacek
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Cardiomyopathy, Hypertrophic - blood
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - pathology
Fibrosis - blood
Fibrosis - diagnosis
galectin-3
GDF-15
Humans
Hypertrophic cardiomyopathy
Hypertrophy - blood
Hypertrophy - diagnosis
Magnetic Resonance Imaging
Middle Aged
myocardial fibrosis
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
sST2
Troponin T - blood
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Summary:Background: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. Objective: The aim of this study was to evaluate usefulness of various biomarkers of myocardial fibrosis and hypertrophy in HCM. Methods: Levels of biomarkers: soluble ST2 (sST2), galectin-3 (Gal-3), growth differentiation factor-15 (GDF-15), NT-proBNP and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis. Results: We observed positive correlations among sST2 levels and left ventricular mass (LVM) (r = 0.32, p = 0.012), LV mass indexed for the body surface area (LVMI) (r = 0.27, p = 0.036) and maximal wall thickness (MWT) (r = 0.31, p = 0.015). No correlation was found between Gal-3 and GDF-15 levels and hypertrophy and fibrosis parameters. We observed positive correlations among hs-cTnT levels and LVM (r = 0.58, p 
ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2018.1474261