Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus

Epidemiologic data suggest that diabetes mellitus type II is a risk factor for several types of cancer, including pancreatic, liver, colon and thyroid cancers. In the present study, effects of diabetes/hyperlipidemia on N-nitrosobis(2-oxopropyl)amine (BOP)-induced cancer development were examined in...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2007-10, Vol.28 (10), p.2193-2198
Main Authors: Sakano, Katsuhisa, Takahashi, Mami, Mutoh, Michihiro, Niho, Naoko, Komiya, Masami, Sato, Hidetaka, Tanaka, Takuji, Sugimura, Takashi, Wakabayashi, Keiji
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - administration & dosage
Carcinogens - toxicity
Colonic Neoplasms - chemically induced
Colonic Neoplasms - pathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Injections, Subcutaneous
Male
Medical sciences
Nitrosamines - administration & dosage
Nitrosamines - toxicity
Rats
Rats, Inbred OLETF
Rats, Long-Evans
Risk Factors
Species Specificity
Thyroid Neoplasms - chemically induced
Thyroid Neoplasms - pathology
Tumors
Citations: Items that cite this one
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Summary:Epidemiologic data suggest that diabetes mellitus type II is a risk factor for several types of cancer, including pancreatic, liver, colon and thyroid cancers. In the present study, effects of diabetes/hyperlipidemia on N-nitrosobis(2-oxopropyl)amine (BOP)-induced cancer development were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, model animals for non-insulin-dependent diabetes mellitus and Long-Evans Tokushima Otsuka (LETO) rats, appropriate controls. Males of both strains were given four subcutaneous injections of BOP (10 mg/kg body wt) or saline on alternative days, starting at 5 weeks of age. BOP induced tumors in a variety of tissues, including the thyroid gland, colon, kidney, liver and lung. The highest yields were noted for thyroid tumors, the incidence (P = 0.0182) and multiplicity (P 
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/bgm114