Electrospray ionization study of tricarbonyl fac‐[Re(CO)3(PO)(X)]‐type complexes: influence of ancillary co‐ligands in the release of carbon monoxide

Rationale fac‐[Re(CO)3(PO)(X)]‐type complexes (PO = chelated bidentate tertiary phosphine (1‐), X = various neutral, mono‐dentate ligands) represent a class of compounds that meets the synthetic criteria for the preparation of potential carbon monoxide (CO) release molecules (CORMs) for medicinal ap...

Full description

Saved in:
Bibliographic Details
Published in:Rapid communications in mass spectrometry 2018-08, Vol.32 (15), p.1199-1206
Main Authors: Tisato, Francesco, Porchia, Marina, Shegani, Antoni, Maina, Theodosia, Papadopoulos, Minas S., Seraglia, Roberta, Traldi, Pietro
Format: Article
Language:English
Subjects:
Carbon monoxide
Controlled release
Coordination compounds
Decomposition
Electrospraying
Imidazole
Investigations
Ionization
Ions
Ligands
Mass spectrometry
Molecular chains
Scientific imaging
Spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rationale fac‐[Re(CO)3(PO)(X)]‐type complexes (PO = chelated bidentate tertiary phosphine (1‐), X = various neutral, mono‐dentate ligands) represent a class of compounds that meets the synthetic criteria for the preparation of potential carbon monoxide (CO) release molecules (CORMs) for medicinal application. The aim of our investigation was to achieve qualitative information whether the nature of the ancillary X ligand might influence the release of CO. Methods The release of CO has been investigated by means of product ion spectrometry of electrospray ionization (ESI)‐generated [M + H]+ species, produced by multiple collisional experiments, using an ion trap mass spectrometer. Results Tandem mass spectrometry applied to the protonated species [Re(CO)3(PO)(X) + H]+ of seven complexes (those including X = OH2 (1), isonitrile (2, 3), imidazole (4), pyridine (5) and phosphine (6, 7)) shows initial loss of coordinated water (1) or pyridine (5), whereas the majority of investigated entries display initial, sequential release of CO groups. The energetics of CO release have been investigated by breakdown curves for selected collisionally activated decomposition processes involving CO, and compared with those involving X groups. Conclusions The nature of the co‐ligand X drives the primary loss in the MSn processes of [Re(CO)3(PO)(X) + H]+ compounds. When X = solvent, the energetics of these decompositions follow the trend H2O 
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.8162