Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis

Objective Calprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC). Study...

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Bibliographic Details
Published in:Journal of perinatology 2018-10, Vol.38 (10), p.1379-1385
Main Authors: MacQueen, B. C., Christensen, R. D., Yost, C. C., Gordon, P. V., Baer, V. L., Schlaberg, R., Lowe, J.
Format: Article
Language:English
Subjects:
692/308/53/2421
692/699/1503
Age
Diagnosis
Diagnostic systems
EF hand proteins
Enterocolitis
Gastrointestinal diseases
Gestational age
Infants
Intervals
Leukocytes (granulocytic)
Medical diagnosis
Medical schools
Medicine
Medicine & Public Health
Necrosis
Necrotizing enterocolitis
Neonates
Newborn babies
Newborn infants
Pediatric research
Pediatric Surgery
Pediatrics
Premature infants
Proteins
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Summary:Objective Calprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC). Study design Stool calprotectin was measured in premature neonates without gastrointestinal pathology to create reference intervals. For comparison, levels from infants undergoing “rule out NEC” evaluations were plotted on these reference intervals. Results Stool calprotectin reference intervals were created according to gestational age at birth and corrected gestational age. Levels during “rule out NEC” evaluations were more often above the upper reference interval with NEC vs. those without NEC. Conclusions Stools from preterm neonates have a higher range of calprotectin than stools from healthy term neonates. In evaluating preterm neonates for NEC with stool calprotectin, a calprotectin upper reference interval that incorporates corrected gestational age best predicts the diagnosis of NEC.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-018-0108-9