Loading…
PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome
Aims Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not elucidated fully. This study evaluates expression patterns in primary H...
Saved in:
| Published in: | Histopathology 2018-10, Vol.73 (4), p.573-584 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53 |
| container_end_page | 584 |
| container_issue | 4 |
| container_start_page | 573 |
| container_title | Histopathology |
| container_volume | 73 |
| creator | Schneider, Sven Kadletz, Lorenz Wiebringhaus, Robert Kenner, Lukas Selzer, Edgar Füreder, Thorsten Rajky, Orsolya Berghoff, Anna S Preusser, Matthias Heiduschka, Gregor |
| description | Aims
Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not elucidated fully. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and the impact on patients’ clinical outcome.
Methods and results
Immunohistochemical staining patterns of PD‐L1 and PD‐1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases. Results were correlated with patients’ clinical data. PD‐L1 expression was observed in 36% of primary carcinoma and 33% of lymph node metastasis, and correlates significantly with decreased overall survival (OS) (P = 0.01) and disease‐free survival (DFS) (P = 0.001) in oral cavity squamous cell carcinoma patients. PD‐L1 expression was associated with presence of lymph node metastasis (P = 0.0223). Infiltration of PD‐1‐expressing lymphocytes correlates significantly with favourable OS (P = 0.001) and DFS (P = 0.001) in oropharyngeal cancer and hypopharyngeal cancer patients OS (P = 0.007) and DFS (P = 0.001). Presence of PD‐1 TILs also correlates significantly with better OS (P = 0.005) and DFS (P = 0) in the human papilloma virus (HPV)‐negative cohort. Cox regression multivariate analysis revealed PD‐1 TIL expression as an independent prognostic marker for OS (P = 0.004) and DFS (P = 0.001) and T stage was validated as negative prognostic marker for OS (P = 0.011). PD‐1‐expressing lymphocytes (P = 0.0412) and PD‐L1 expression (P = 0.0022) patterns correlate significantly in primary cancers and matched lymph node metastases.
Conclusions
Our results characterise the expression profiles of PD‐1 axis proteins in HNSCC which might serve as possible clinical prognostic markers. |
| doi_str_mv | 10.1111/his.13646 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2037046532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2037046532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53</originalsourceid><addsrcrecordid>eNp1kctKAzEUhoMoWi8LX0ACbnQxmstkpllKvVQoKlTXIU1OaWRuJjNqdz6C4Bv6JMa2uhAMgZPFx0fO_yO0T8kJjed05sIJ5VmaraFenCJhQsh11COcyITQLN9C2yE8EkJzztgm2mIyTxmTtIee784_394p1pXFi-eIYnhtPITg6gq7Cg9vxoMBbrwrtZ9joysDfoF7KHQLFhfzspnhqraAS2h1iNcF_Pn2gV3ZaNPi6DGFq5zRBa671tQl7KKNqS4C7K3mDnq4vLgfDJPR7dX14GyUmJTKLEnNRBpqCeN2khmWWSEo00xwIPnU5kznOu0LkfUN5ZbZvowbE5BTaUGzdCL4DjpaehtfP3UQWlW6YKAodAV1FxQjPCdpJjiL6OEf9LHufBV_p1gMmeTf4UXqeEkZX4fgYapWyShK1HcZKpahFmVE9mBl7CYl2F_yJ_0InC6BF1fA_H-TGl6Pl8ov9UCUPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2111071732</pqid></control><display><type>article</type><title>PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Schneider, Sven ; Kadletz, Lorenz ; Wiebringhaus, Robert ; Kenner, Lukas ; Selzer, Edgar ; Füreder, Thorsten ; Rajky, Orsolya ; Berghoff, Anna S ; Preusser, Matthias ; Heiduschka, Gregor</creator><creatorcontrib>Schneider, Sven ; Kadletz, Lorenz ; Wiebringhaus, Robert ; Kenner, Lukas ; Selzer, Edgar ; Füreder, Thorsten ; Rajky, Orsolya ; Berghoff, Anna S ; Preusser, Matthias ; Heiduschka, Gregor</creatorcontrib><description>Aims
Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not elucidated fully. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and the impact on patients’ clinical outcome.
Methods and results
Immunohistochemical staining patterns of PD‐L1 and PD‐1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases. Results were correlated with patients’ clinical data. PD‐L1 expression was observed in 36% of primary carcinoma and 33% of lymph node metastasis, and correlates significantly with decreased overall survival (OS) (P = 0.01) and disease‐free survival (DFS) (P = 0.001) in oral cavity squamous cell carcinoma patients. PD‐L1 expression was associated with presence of lymph node metastasis (P = 0.0223). Infiltration of PD‐1‐expressing lymphocytes correlates significantly with favourable OS (P = 0.001) and DFS (P = 0.001) in oropharyngeal cancer and hypopharyngeal cancer patients OS (P = 0.007) and DFS (P = 0.001). Presence of PD‐1 TILs also correlates significantly with better OS (P = 0.005) and DFS (P = 0) in the human papilloma virus (HPV)‐negative cohort. Cox regression multivariate analysis revealed PD‐1 TIL expression as an independent prognostic marker for OS (P = 0.004) and DFS (P = 0.001) and T stage was validated as negative prognostic marker for OS (P = 0.011). PD‐1‐expressing lymphocytes (P = 0.0412) and PD‐L1 expression (P = 0.0022) patterns correlate significantly in primary cancers and matched lymph node metastases.
Conclusions
Our results characterise the expression profiles of PD‐1 axis proteins in HNSCC which might serve as possible clinical prognostic markers.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13646</identifier><identifier>PMID: 29742291</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Apoptosis ; B7-H1 Antigen - biosynthesis ; Biomarkers, Tumor - analysis ; Biopsy ; Cancer ; Cell death ; Disease-Free Survival ; Female ; Head & neck cancer ; HNSCC ; Human papillomavirus ; Humans ; immunohistochemistry ; Kaplan-Meier Estimate ; lymph node metastasis ; Lymph nodes ; Lymphatic Metastasis - pathology ; Lymphatic system ; Lymphocytes ; Lymphocytes, Tumor-Infiltrating - pathology ; Male ; Metastases ; Metastasis ; Middle Aged ; Multivariate analysis ; Oral cavity ; Oropharyngeal cancer ; PD-1 protein ; PD-L1 protein ; PD‐1 ; PD‐L1 ; Prognosis ; Programmed Cell Death 1 Receptor - biosynthesis ; Proportional Hazards Models ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - mortality ; Squamous Cell Carcinoma of Head and Neck - pathology ; TIL ; Tumors</subject><ispartof>Histopathology, 2018-10, Vol.73 (4), p.573-584</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53</citedby><cites>FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53</cites><orcidid>0000-0002-7631-3746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29742291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schneider, Sven</creatorcontrib><creatorcontrib>Kadletz, Lorenz</creatorcontrib><creatorcontrib>Wiebringhaus, Robert</creatorcontrib><creatorcontrib>Kenner, Lukas</creatorcontrib><creatorcontrib>Selzer, Edgar</creatorcontrib><creatorcontrib>Füreder, Thorsten</creatorcontrib><creatorcontrib>Rajky, Orsolya</creatorcontrib><creatorcontrib>Berghoff, Anna S</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><creatorcontrib>Heiduschka, Gregor</creatorcontrib><title>PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not elucidated fully. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and the impact on patients’ clinical outcome.
Methods and results
Immunohistochemical staining patterns of PD‐L1 and PD‐1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases. Results were correlated with patients’ clinical data. PD‐L1 expression was observed in 36% of primary carcinoma and 33% of lymph node metastasis, and correlates significantly with decreased overall survival (OS) (P = 0.01) and disease‐free survival (DFS) (P = 0.001) in oral cavity squamous cell carcinoma patients. PD‐L1 expression was associated with presence of lymph node metastasis (P = 0.0223). Infiltration of PD‐1‐expressing lymphocytes correlates significantly with favourable OS (P = 0.001) and DFS (P = 0.001) in oropharyngeal cancer and hypopharyngeal cancer patients OS (P = 0.007) and DFS (P = 0.001). Presence of PD‐1 TILs also correlates significantly with better OS (P = 0.005) and DFS (P = 0) in the human papilloma virus (HPV)‐negative cohort. Cox regression multivariate analysis revealed PD‐1 TIL expression as an independent prognostic marker for OS (P = 0.004) and DFS (P = 0.001) and T stage was validated as negative prognostic marker for OS (P = 0.011). PD‐1‐expressing lymphocytes (P = 0.0412) and PD‐L1 expression (P = 0.0022) patterns correlate significantly in primary cancers and matched lymph node metastases.
Conclusions
Our results characterise the expression profiles of PD‐1 axis proteins in HNSCC which might serve as possible clinical prognostic markers.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>B7-H1 Antigen - biosynthesis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>HNSCC</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>lymph node metastasis</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes, Tumor-Infiltrating - pathology</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Oral cavity</subject><subject>Oropharyngeal cancer</subject><subject>PD-1 protein</subject><subject>PD-L1 protein</subject><subject>PD‐1</subject><subject>PD‐L1</subject><subject>Prognosis</subject><subject>Programmed Cell Death 1 Receptor - biosynthesis</subject><subject>Proportional Hazards Models</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - mortality</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><subject>TIL</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kctKAzEUhoMoWi8LX0ACbnQxmstkpllKvVQoKlTXIU1OaWRuJjNqdz6C4Bv6JMa2uhAMgZPFx0fO_yO0T8kJjed05sIJ5VmaraFenCJhQsh11COcyITQLN9C2yE8EkJzztgm2mIyTxmTtIee784_394p1pXFi-eIYnhtPITg6gq7Cg9vxoMBbrwrtZ9joysDfoF7KHQLFhfzspnhqraAS2h1iNcF_Pn2gV3ZaNPi6DGFq5zRBa671tQl7KKNqS4C7K3mDnq4vLgfDJPR7dX14GyUmJTKLEnNRBpqCeN2khmWWSEo00xwIPnU5kznOu0LkfUN5ZbZvowbE5BTaUGzdCL4DjpaehtfP3UQWlW6YKAodAV1FxQjPCdpJjiL6OEf9LHufBV_p1gMmeTf4UXqeEkZX4fgYapWyShK1HcZKpahFmVE9mBl7CYl2F_yJ_0InC6BF1fA_H-TGl6Pl8ov9UCUPQ</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Schneider, Sven</creator><creator>Kadletz, Lorenz</creator><creator>Wiebringhaus, Robert</creator><creator>Kenner, Lukas</creator><creator>Selzer, Edgar</creator><creator>Füreder, Thorsten</creator><creator>Rajky, Orsolya</creator><creator>Berghoff, Anna S</creator><creator>Preusser, Matthias</creator><creator>Heiduschka, Gregor</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7631-3746</orcidid></search><sort><creationdate>201810</creationdate><title>PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome</title><author>Schneider, Sven ; Kadletz, Lorenz ; Wiebringhaus, Robert ; Kenner, Lukas ; Selzer, Edgar ; Füreder, Thorsten ; Rajky, Orsolya ; Berghoff, Anna S ; Preusser, Matthias ; Heiduschka, Gregor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>B7-H1 Antigen - biosynthesis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>HNSCC</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>lymph node metastasis</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphocytes, Tumor-Infiltrating - pathology</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Oral cavity</topic><topic>Oropharyngeal cancer</topic><topic>PD-1 protein</topic><topic>PD-L1 protein</topic><topic>PD‐1</topic><topic>PD‐L1</topic><topic>Prognosis</topic><topic>Programmed Cell Death 1 Receptor - biosynthesis</topic><topic>Proportional Hazards Models</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - mortality</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><topic>TIL</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schneider, Sven</creatorcontrib><creatorcontrib>Kadletz, Lorenz</creatorcontrib><creatorcontrib>Wiebringhaus, Robert</creatorcontrib><creatorcontrib>Kenner, Lukas</creatorcontrib><creatorcontrib>Selzer, Edgar</creatorcontrib><creatorcontrib>Füreder, Thorsten</creatorcontrib><creatorcontrib>Rajky, Orsolya</creatorcontrib><creatorcontrib>Berghoff, Anna S</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><creatorcontrib>Heiduschka, Gregor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schneider, Sven</au><au>Kadletz, Lorenz</au><au>Wiebringhaus, Robert</au><au>Kenner, Lukas</au><au>Selzer, Edgar</au><au>Füreder, Thorsten</au><au>Rajky, Orsolya</au><au>Berghoff, Anna S</au><au>Preusser, Matthias</au><au>Heiduschka, Gregor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2018-10</date><risdate>2018</risdate><volume>73</volume><issue>4</issue><spage>573</spage><epage>584</epage><pages>573-584</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
Expression profiles and clinical impact of programmed cell death ligand 1 (PD‐L1) and programmed cell death 1 (PD‐1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not elucidated fully. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and the impact on patients’ clinical outcome.
Methods and results
Immunohistochemical staining patterns of PD‐L1 and PD‐1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases. Results were correlated with patients’ clinical data. PD‐L1 expression was observed in 36% of primary carcinoma and 33% of lymph node metastasis, and correlates significantly with decreased overall survival (OS) (P = 0.01) and disease‐free survival (DFS) (P = 0.001) in oral cavity squamous cell carcinoma patients. PD‐L1 expression was associated with presence of lymph node metastasis (P = 0.0223). Infiltration of PD‐1‐expressing lymphocytes correlates significantly with favourable OS (P = 0.001) and DFS (P = 0.001) in oropharyngeal cancer and hypopharyngeal cancer patients OS (P = 0.007) and DFS (P = 0.001). Presence of PD‐1 TILs also correlates significantly with better OS (P = 0.005) and DFS (P = 0) in the human papilloma virus (HPV)‐negative cohort. Cox regression multivariate analysis revealed PD‐1 TIL expression as an independent prognostic marker for OS (P = 0.004) and DFS (P = 0.001) and T stage was validated as negative prognostic marker for OS (P = 0.011). PD‐1‐expressing lymphocytes (P = 0.0412) and PD‐L1 expression (P = 0.0022) patterns correlate significantly in primary cancers and matched lymph node metastases.
Conclusions
Our results characterise the expression profiles of PD‐1 axis proteins in HNSCC which might serve as possible clinical prognostic markers.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29742291</pmid><doi>10.1111/his.13646</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7631-3746</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0309-0167 |
| ispartof | Histopathology, 2018-10, Vol.73 (4), p.573-584 |
| issn | 0309-0167 1365-2559 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2037046532 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Aged, 80 and over Apoptosis B7-H1 Antigen - biosynthesis Biomarkers, Tumor - analysis Biopsy Cancer Cell death Disease-Free Survival Female Head & neck cancer HNSCC Human papillomavirus Humans immunohistochemistry Kaplan-Meier Estimate lymph node metastasis Lymph nodes Lymphatic Metastasis - pathology Lymphatic system Lymphocytes Lymphocytes, Tumor-Infiltrating - pathology Male Metastases Metastasis Middle Aged Multivariate analysis Oral cavity Oropharyngeal cancer PD-1 protein PD-L1 protein PD‐1 PD‐L1 Prognosis Programmed Cell Death 1 Receptor - biosynthesis Proportional Hazards Models Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - mortality Squamous Cell Carcinoma of Head and Neck - pathology TIL Tumors |
| title | PD‐1 and PD‐L1 expression in HNSCC primary cancer and related lymph node metastasis – impact on clinical outcome |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T14%3A51%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PD%E2%80%901%20and%20PD%E2%80%90L1%20expression%20in%20HNSCC%20primary%20cancer%20and%20related%20lymph%20node%20metastasis%20%E2%80%93%20impact%20on%20clinical%20outcome&rft.jtitle=Histopathology&rft.au=Schneider,%20Sven&rft.date=2018-10&rft.volume=73&rft.issue=4&rft.spage=573&rft.epage=584&rft.pages=573-584&rft.issn=0309-0167&rft.eissn=1365-2559&rft_id=info:doi/10.1111/his.13646&rft_dat=%3Cproquest_cross%3E2037046532%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4196-4cb9c1d023db6c26d5512a253e07fd72a7a485568c13d2d890300e9f9dea24b53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2111071732&rft_id=info:pmid/29742291&rfr_iscdi=true |