Recent advances in synthetic biology of cyanobacteria

Cyanobacteria are attractive hosts that can be engineered for the photosynthetic production of fuels, fine chemicals, and proteins from CO 2 . Moreover, the responsiveness of these photoautotrophs towards different environmental signals, such as light, CO 2 , diurnal cycle, and metals make them pote...

Full description

Saved in:
Bibliographic Details
Published in:Applied microbiology and biotechnology 2018-07, Vol.102 (13), p.5457-5471
Main Authors: Sengupta, Annesha, Pakrasi, Himadri B., Wangikar, Pramod P.
Format: Article
Language:English
Subjects:
Bioengineering
Biofuels
Biological activity
Biology
Biomedical and Life Sciences
Biosensing Techniques
Biosensors
Biosynthesis
Biotechnology
Carbon dioxide
Chassis
Cyanobacteria
Cyanobacteria - genetics
Cyanobacteria - physiology
Diurnal
Diurnal variations
Fine chemicals
Forecasts and trends
Genetic Engineering
Heterotrophic organisms
Industrial engineering
Life Sciences
Manufacturing engineering
Metals
Microbial Genetics and Genomics
Microbiology
Mini-Review
Organic chemistry
Photosynthesis
Physiological aspects
Proteins
Synthetic biology
Synthetic Biology - methods
Synthetic Biology - trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cyanobacteria are attractive hosts that can be engineered for the photosynthetic production of fuels, fine chemicals, and proteins from CO 2 . Moreover, the responsiveness of these photoautotrophs towards different environmental signals, such as light, CO 2 , diurnal cycle, and metals make them potential hosts for the development of biosensors. However, engineering these hosts proves to be a challenging and lengthy process. Synthetic biology can make the process of biological engineering more predictable through the use of standardized biological parts that are well characterized and tools to assemble them. While significant progress has been made with model heterotrophic organisms, many of the parts and tools are not portable in cyanobacteria. Therefore, efforts are underway to develop and characterize parts derived from cyanobacteria. In this review, we discuss the reported parts and tools with the objective to develop cyanobacteria as cell factories or biosensors. We also discuss the issues related to characterization, tunability, portability, and the need to develop enabling technologies to engineer this “green” chassis.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-018-9046-x