Metal‐Catalyzed Remote Functionalization of ω‐Ene Unsaturated Ethers: Towards Functionalized Vinyl Species

The combined ruthenium‐catalyzed chain walking with the nickel‐catalyzed cross‐coupling reaction of ω‐alkenyl ethers provide a unique entry to functionalized vinyl species. This transformation illustrates the power and flexibility of remote functionalization by demonstrating the compatibility of two...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-07, Vol.57 (27), p.8012-8016
Main Authors: Ho, Guo‐Ming, Judkele, Lina, Bruffaerts, Jeffrey, Marek, Ilan
Format: Article
Language:English
Subjects:
cross-coupling
Ethers
isomerization
Nickel
remote functionalization
Ruthenium
zirconium
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Summary:The combined ruthenium‐catalyzed chain walking with the nickel‐catalyzed cross‐coupling reaction of ω‐alkenyl ethers provide a unique entry to functionalized vinyl species. This transformation illustrates the power and flexibility of remote functionalization by demonstrating the compatibility of two independent reactions involving unrelated sites. Walking a tightrope: The combined ruthenium‐catalyzed chain walking with the nickel‐catalyzed cross‐coupling reaction of ω‐alkenyl ethers provide a unique entry to functionalized vinyl species. This transformation illustrates the power and flexibility of remote functionalization by demonstrating the compatibility of two independent reactions involving unrelated sites.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201802434