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Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population
Paraoxonase‐1 (PON1) is a serum esterase associated with high density lipoproteins and capable of detoxifying toxic metabolites of organophosphorus (OP) compounds. Two major polymorphisms have been described in the coding region of the PON1 gene at positions 192 and 55 and at least five in the 5′‐re...
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Published in: | Environmental and molecular mutagenesis 2006-12, Vol.47 (9), p.699-706 |
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description | Paraoxonase‐1 (PON1) is a serum esterase associated with high density lipoproteins and capable of detoxifying toxic metabolites of organophosphorus (OP) compounds. Two major polymorphisms have been described in the coding region of the PON1 gene at positions 192 and 55 and at least five in the 5′‐regulatory region, the most important at position −108. Depending on the substrate, PON1 192 Q/R polymorphism can affect PON1 enzymatic activity. In the present study, we have determined the distribution of the PON1 192 Q/R and −108 C/T polymorphisms in a Peruvian population and compared the distribution of these polymorphisms with those of other world populations. PON1 phenotype and enzyme activity also were measured as they can influence the population resistance to the toxicity of OP compounds. The genotype distribution at position 192 was: QQ = 0.236, QR = 0.607, and RR = 0.157; and distribution at position −108 was: CC = 0.315, CT = 0.596, and TT = 0.089. The frequencies of the high activity R and C alleles were 0.461 and 0.613, respectively. The frequency of the PON1 192 Q allele was significantly lower than that of American, Caucasian‐American, European‐Brazilian, and Costa Rican samples. Outside the American continent, the frequency of this allele was lower than for all European countries, Thais, and Indians, but higher than for Chinese or Japanese. Regarding the toxicological importance of these polymorphisms, it was inferred that PON1 phenotyping (assessment of the R alloform) and genotyping (determination of the PON1 –108TT genotype) could be helpful as individual markers of susceptibility. PON1 phenotyping may be useful in further epidemiological studies involving agriculture workers occupationally exposed to OP compounds in developing countries. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/em.20259 |
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Two major polymorphisms have been described in the coding region of the PON1 gene at positions 192 and 55 and at least five in the 5′‐regulatory region, the most important at position −108. Depending on the substrate, PON1 192 Q/R polymorphism can affect PON1 enzymatic activity. In the present study, we have determined the distribution of the PON1 192 Q/R and −108 C/T polymorphisms in a Peruvian population and compared the distribution of these polymorphisms with those of other world populations. PON1 phenotype and enzyme activity also were measured as they can influence the population resistance to the toxicity of OP compounds. The genotype distribution at position 192 was: QQ = 0.236, QR = 0.607, and RR = 0.157; and distribution at position −108 was: CC = 0.315, CT = 0.596, and TT = 0.089. The frequencies of the high activity R and C alleles were 0.461 and 0.613, respectively. The frequency of the PON1 192 Q allele was significantly lower than that of American, Caucasian‐American, European‐Brazilian, and Costa Rican samples. Outside the American continent, the frequency of this allele was lower than for all European countries, Thais, and Indians, but higher than for Chinese or Japanese. Regarding the toxicological importance of these polymorphisms, it was inferred that PON1 phenotyping (assessment of the R alloform) and genotyping (determination of the PON1 –108TT genotype) could be helpful as individual markers of susceptibility. PON1 phenotyping may be useful in further epidemiological studies involving agriculture workers occupationally exposed to OP compounds in developing countries. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0893-6692</identifier><identifier>EISSN: 1098-2280</identifier><identifier>DOI: 10.1002/em.20259</identifier><identifier>PMID: 17078098</identifier><identifier>CODEN: EMMUEG</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aryldialkylphosphatase - genetics ; Aryldialkylphosphatase - metabolism ; Biological and medical sciences ; biomarkers of susceptibility ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; Humans ; Male ; Medical sciences ; molecular epidemiology ; organophosphates ; Organophosphorus Compounds ; Peru ; Peruvian population ; Pesticides ; Polymorphism, Genetic ; PON1 polymorphisms ; Toxicology</subject><ispartof>Environmental and molecular mutagenesis, 2006-12, Vol.47 (9), p.699-706</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5159-b91aa9171d4c6ddbf9b0cc90705a0f956773db42321b8c62b09a8bbc42d140543</citedby><cites>FETCH-LOGICAL-c5159-b91aa9171d4c6ddbf9b0cc90705a0f956773db42321b8c62b09a8bbc42d140543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18588959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17078098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cataño, Héctor C.</creatorcontrib><creatorcontrib>Cueva, Jayme L.</creatorcontrib><creatorcontrib>Cardenas, Anthony M.</creatorcontrib><creatorcontrib>Izaguirre, VÍctor</creatorcontrib><creatorcontrib>Zavaleta, Amparo I.</creatorcontrib><creatorcontrib>Carranza, Elizabeth</creatorcontrib><creatorcontrib>Hernández, Antonio F.</creatorcontrib><title>Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population</title><title>Environmental and molecular mutagenesis</title><addtitle>Environ. Mol. Mutagen</addtitle><description>Paraoxonase‐1 (PON1) is a serum esterase associated with high density lipoproteins and capable of detoxifying toxic metabolites of organophosphorus (OP) compounds. Two major polymorphisms have been described in the coding region of the PON1 gene at positions 192 and 55 and at least five in the 5′‐regulatory region, the most important at position −108. Depending on the substrate, PON1 192 Q/R polymorphism can affect PON1 enzymatic activity. In the present study, we have determined the distribution of the PON1 192 Q/R and −108 C/T polymorphisms in a Peruvian population and compared the distribution of these polymorphisms with those of other world populations. PON1 phenotype and enzyme activity also were measured as they can influence the population resistance to the toxicity of OP compounds. The genotype distribution at position 192 was: QQ = 0.236, QR = 0.607, and RR = 0.157; and distribution at position −108 was: CC = 0.315, CT = 0.596, and TT = 0.089. The frequencies of the high activity R and C alleles were 0.461 and 0.613, respectively. The frequency of the PON1 192 Q allele was significantly lower than that of American, Caucasian‐American, European‐Brazilian, and Costa Rican samples. Outside the American continent, the frequency of this allele was lower than for all European countries, Thais, and Indians, but higher than for Chinese or Japanese. Regarding the toxicological importance of these polymorphisms, it was inferred that PON1 phenotyping (assessment of the R alloform) and genotyping (determination of the PON1 –108TT genotype) could be helpful as individual markers of susceptibility. PON1 phenotyping may be useful in further epidemiological studies involving agriculture workers occupationally exposed to OP compounds in developing countries. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Aryldialkylphosphatase - metabolism</subject><subject>Biological and medical sciences</subject><subject>biomarkers of susceptibility</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>molecular epidemiology</subject><subject>organophosphates</subject><subject>Organophosphorus Compounds</subject><subject>Peru</subject><subject>Peruvian population</subject><subject>Pesticides</subject><subject>Polymorphism, Genetic</subject><subject>PON1 polymorphisms</subject><subject>Toxicology</subject><issn>0893-6692</issn><issn>1098-2280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqN0V9r1TAYx_Egijubgq9AcqN405mkTZNcyjanOP-AE2Eg4UmaarRNatJuq6_enp3qrgSvcvPh-8AvCD2i5JASwp67_pARxtUdtKFEyYIxSe6iDZGqLOpasT20n_N3QiitFLuP9qggQi5wg74c-zwmb6bRx4BjiwdIEK9jgOwKir-64PAQu7mPafjmc58xhAa78GvuHQY7-ks_ztgHDPiDS9Olh7D4YepgG3yA7rXQZfdwfQ_Qp5cn50evirP3p6-PXpwVllOuCqMogKKCNpWtm8a0yhBrFRGEA2kVr4UoG1OxklEjbc0MUSCNsRVraEV4VR6gp7vukOLPyeVR9z5b13UQXJyyZqQUilH-H5AtG4lt8dkO2hRzTq7VQ_I9pFlToreba9frm80X-nhtTqZ3zS1cR17AkxVAttC1CYL1-dZJLqW6CRU7d-U7N__zoD55--fw6pcvdNd_PaQfuhal4Przu1P95vhcfqwuan1R_gYMsqag</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Cataño, Héctor C.</creator><creator>Cueva, Jayme L.</creator><creator>Cardenas, Anthony M.</creator><creator>Izaguirre, VÍctor</creator><creator>Zavaleta, Amparo I.</creator><creator>Carranza, Elizabeth</creator><creator>Hernández, Antonio F.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>200612</creationdate><title>Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population</title><author>Cataño, Héctor C. ; Cueva, Jayme L. ; Cardenas, Anthony M. ; Izaguirre, VÍctor ; Zavaleta, Amparo I. ; Carranza, Elizabeth ; Hernández, Antonio F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5159-b91aa9171d4c6ddbf9b0cc90705a0f956773db42321b8c62b09a8bbc42d140543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Aryldialkylphosphatase - metabolism</topic><topic>Biological and medical sciences</topic><topic>biomarkers of susceptibility</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>molecular epidemiology</topic><topic>organophosphates</topic><topic>Organophosphorus Compounds</topic><topic>Peru</topic><topic>Peruvian population</topic><topic>Pesticides</topic><topic>Polymorphism, Genetic</topic><topic>PON1 polymorphisms</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cataño, Héctor C.</creatorcontrib><creatorcontrib>Cueva, Jayme L.</creatorcontrib><creatorcontrib>Cardenas, Anthony M.</creatorcontrib><creatorcontrib>Izaguirre, VÍctor</creatorcontrib><creatorcontrib>Zavaleta, Amparo I.</creatorcontrib><creatorcontrib>Carranza, Elizabeth</creatorcontrib><creatorcontrib>Hernández, Antonio F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Environmental and molecular mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cataño, Héctor C.</au><au>Cueva, Jayme L.</au><au>Cardenas, Anthony M.</au><au>Izaguirre, VÍctor</au><au>Zavaleta, Amparo I.</au><au>Carranza, Elizabeth</au><au>Hernández, Antonio F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population</atitle><jtitle>Environmental and molecular mutagenesis</jtitle><addtitle>Environ. Mol. Mutagen</addtitle><date>2006-12</date><risdate>2006</risdate><volume>47</volume><issue>9</issue><spage>699</spage><epage>706</epage><pages>699-706</pages><issn>0893-6692</issn><eissn>1098-2280</eissn><coden>EMMUEG</coden><abstract>Paraoxonase‐1 (PON1) is a serum esterase associated with high density lipoproteins and capable of detoxifying toxic metabolites of organophosphorus (OP) compounds. Two major polymorphisms have been described in the coding region of the PON1 gene at positions 192 and 55 and at least five in the 5′‐regulatory region, the most important at position −108. Depending on the substrate, PON1 192 Q/R polymorphism can affect PON1 enzymatic activity. In the present study, we have determined the distribution of the PON1 192 Q/R and −108 C/T polymorphisms in a Peruvian population and compared the distribution of these polymorphisms with those of other world populations. PON1 phenotype and enzyme activity also were measured as they can influence the population resistance to the toxicity of OP compounds. The genotype distribution at position 192 was: QQ = 0.236, QR = 0.607, and RR = 0.157; and distribution at position −108 was: CC = 0.315, CT = 0.596, and TT = 0.089. The frequencies of the high activity R and C alleles were 0.461 and 0.613, respectively. The frequency of the PON1 192 Q allele was significantly lower than that of American, Caucasian‐American, European‐Brazilian, and Costa Rican samples. Outside the American continent, the frequency of this allele was lower than for all European countries, Thais, and Indians, but higher than for Chinese or Japanese. Regarding the toxicological importance of these polymorphisms, it was inferred that PON1 phenotyping (assessment of the R alloform) and genotyping (determination of the PON1 –108TT genotype) could be helpful as individual markers of susceptibility. PON1 phenotyping may be useful in further epidemiological studies involving agriculture workers occupationally exposed to OP compounds in developing countries. Environ. Mol. Mutagen. 47:, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17078098</pmid><doi>10.1002/em.20259</doi><tpages>8</tpages></addata></record> |
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subjects | Adolescent Adult Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Biological and medical sciences biomarkers of susceptibility Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetics of eukaryotes. Biological and molecular evolution Genotype Humans Male Medical sciences molecular epidemiology organophosphates Organophosphorus Compounds Peru Peruvian population Pesticides Polymorphism, Genetic PON1 polymorphisms Toxicology |
title | Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population |
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