Novel usage of microfocus computed tomography (micro‐CT) for visualisation of human embryonic development—Implications for future non‐invasive post‐mortem investigation

What's already known about this topic? Accurate pathological assessment of small gestational age fetuses is challenging. Dating an embryo/fetus is essential to recognise expected human developmental stages and prevent misdiagnosis. What does this study add? Micro‐CT offers a non‐destructive, di...

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Bibliographic Details
Published in:Prenatal diagnosis 2018-06, Vol.38 (7), p.538-542
Main Authors: Shelmerdine, Susan Cheng, Hutchinson, John Ciaran, Kang, Xin, Suich, Joseph D., Ashworth, Michael, Cannie, Mieke M., Segers, Valerie, Sebire, Neil J., Jani, Jacques C., Arthurs, Owen J.
Format: Article
Language:English
Subjects:
Autopsies
Autopsy
Computed tomography
Dating
Dating techniques
Developmental stages
Digital imaging
Embryo, Mammalian - diagnostic imaging
Embryogenesis
Embryonic growth stage
Embryos
Fetuses
Gestation
Gestational age
Humans
X-Ray Microtomography
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Summary:What's already known about this topic? Accurate pathological assessment of small gestational age fetuses is challenging. Dating an embryo/fetus is essential to recognise expected human developmental stages and prevent misdiagnosis. What does this study add? Micro‐CT offers a non‐destructive, digital method for dating human embryos. The micro‐CT imaging here is of the earliest gestation human embryo published to date with corresponding pathology. It can provide an alternative to autopsy even at early stages of development.
ISSN:0197-3851
1097-0223
DOI:10.1002/pd.5281