Ocular surface squamous neoplasia: analysis based on the 8th American Joint Committee on Cancer classification

• Published in: International ophthalmology 2019-06, Vol.39 (6), p.1283-1291
• Main Authors: Singh, Swati, Mohamed, Ashik, Kaliki, Swathi
• Format: Article
• Language: English
• Subjects: Cancer; Classification; Comparative studies; Cornea; Eye (anatomy); Eye cancer; Eye diseases; Fornix; Lymph nodes; Lymphatic system; Medicine; Medicine & Public Health; Metastases; Metastasis; Ophthalmology; Original Paper; Patients; Squamous cell carcinoma; Tumors
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-018-0943-x

Purpose To evaluate outcomes of ocular surface squamous neoplasia (OSSN) based on American Joint Committee on Cancer (AJCC), 8th edition classification. Methods Retrospective, non-randomized interventional case series of 127 patients (136 eyes) with OSSN. Results On the basis of the AJCC (eighth edition), OSSN was classified as per T category as Tis ( n  = 14, 10%), T1 ( n  = 0), T2 ( n  = 4, 3%), T3 ( n  = 113, 83%), and T4 ( n  = 5, 4%). The following parameters increased with increasing T category: mean age at presentation at 37 years for Tis, 43 years for T2, 46 years for T3, and 55 years for T4 ( p  = 0.04); mean tumor basal diameter of 4 mm for Tis, not applicable (na) for T1, 6 mm for T2, 7 mm for T3, 20 mm for T4 ( p  = 0.001); extent of clock hours of corneal involvement (0, na, 0, 4, 8; p  = 0.02), and conjunctival involvement (1, na, 2, 3, 9; p  = 0.0005); involvement of adjacent structures including fornix (0%, na, 0, 9, 80%; p